HNRNPK
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Official Full Name
heterogeneous nuclear ribonucleoprotein K -
Overview
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008] -
Synonyms
HNRNPK;heterogeneous nuclear ribonucleoprotein K;CSBP;TUNP;HNRPK;dC-stretch binding protein;transformation upregulated nuclear protein
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
HNRNPK involved in several pathways and played different roles in them. We selected most pathways HNRNPK participated on our site, such as Spliceosome,Herpes simplex infection,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | RHOA,FZD3,APC,PRKCB,BCL2,RECK,EZR,BMI1,HMOX1,ZEB1 |
| Viral carcinogenesis | TRAF1,ACTN3,HLA-A,HDAC11,HIST1H4M,HRAS,MAD1L1,HDAC1,RBL1,HIST1H2BP |
| Spliceosome | SF3B3,RBM25,HSP70L,NCBP2,PRPF19,SNRNP200,PRP19,NCBP1,SNW1,SNRPD3 |
| Herpes simplex infection | TRAF3,TP53,PPP1CA,C3,PER1,PER2,CSNK2A2,MAVS,Ccl12,LOC100033925 |
Protein Function
HNRNPK has several biochemical functions, for example, RNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPK itself. We selected most functions HNRNPK had, and list some proteins which have the same functions with HNRNPK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | THOC5,SARS,BARD1,RPL18,PAPOLA,IGF2BP2A,RBMS2,TIMM50,TRIM71,NANOS3 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | TCF7L2,ZNF680,MYF6,ZNF217,SREBF2,NR4A3,DDIT3,ZNF395,ELF4,ZNF562 |
| single-stranded DNA binding | RPA3,NCL,BRCA2,NEIL3,NABP2,NME2,PMS1,NUP35,NABP1,PURA |
| poly(A) RNA binding | PSIP1,KIAA1324,FXR2,ZCRB1,MTDH,HIST1H1D,NVL,TRMT6,LSM6,KRR1 |
| protein binding | UBQLN4,GPI1,RYBP,SH2B3,APOE,ZC3H18,AKR1A1,UBAP2L,HDC,ZBTB6 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PATZ1,PAX8,SMAD1,FOXA1,ZFP639,NFIA,MYC,CARF,ZNF750,MEIS1 |
Interacting Protein
HNRNPK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPK here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPK.
RBMX;GRB2;CIRBP;p29846-pro_0000037666
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References
- Guitard, E; Barlat, I; et al. Sam68 is a Ras-GAP-associated protein in mitosis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 245:562-566(1998).
- Hamrita, B; Chahed, K; et al. Identification of tumor antigens that elicit a humoral immune response in breast cancer patients' sera by serological proteome analysis (SERPA). CLINICA CHIMICA ACTA 393:95-102(2008).
- Stains, JP; Lecanda, F; et al. Heterogeneous nuclear ribonucleoprotein K represses transcription from a cytosine/thymidine-rich element in the osteocalcin promoter. BIOCHEMICAL JOURNAL 385:613-623(2005).
- Evans, JR; Mitchell, SA; et al. Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo. ONCOGENE 22:8012-8020(2003).
Reviews
Yes, we received the protein and did our experiments. The protein works. Thank you for taking care of sending it on time and inquiring!!
