HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | CD209A,STX12,TUBA1L2,FCGR3A,TUBA8L4,HBL4,ATP6V1E1,CALR3B,STX7,ATP6V0CB |
| Cell adhesion molecules (CAMs) | ITGB1A,MAG,MHC2DAB,CD226,CLDN15LB,PDCD1LG2,PVRL3B,H2-AB1,CLDNE,HLA-DQA1 |
| Epstein-Barr virus infection | NFKB2,HSPA2,POLR3E,HLA-DPA1,IL10RB,TP53,GTF2B,MAPK8,HLA-DRB4,TBP |
| Type I diabetes mellitus | IFNG,ICA1,GZMB,HLA-DRA,HLA-DQA1,FAS,CPE,CD86,HLA-DPB1,TNF |
| Autoi | HLA-DOB,HLA-DMA,HLA-DMB,IFNA6,HLA-DQB1,Fasl,FAS,IFNA21,TSHB,TSHR |
| HTLV-I infection | HLA-DOB,H2-Q10,RELB,DVL1,IL15,CCND1,XPO1,STAT5B,BUB3,PDGFRB |
| Endocytosis | SH3GL1B,SMAD3,HGS,VPS37A,ARRB2B,TSG101,CXCR4B,TFR1A,PIP5K1AB,RAB4A |
| Viral myocarditis | CD40LG,CD28,ICAM1,H2-AB1,HLA-C,RAC2,BID,ITGB2,RAC1,Casp3 |
| Antigen processing and presentation | HSPA5,HLA-DQB1,H2-AB1,HLA-DMB,HLA-DRB4,HLA-DRB3,HSPA1B,HLA-DOA,HLA-DQA1,HLA-C |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | MHC1UBA,MHC1UDA,TAPBP,HLA-DRB4,H2-AB1,CD209,MHC1UJA,HLA-DQA1,MHC1ZBA,MHC1UKA |
| TAP2 binding | TAPBP,TAP1 |
| TAP1 binding | TAP1,TAPBP,TAP2 |
| receptor binding | CRH,APOF,NTF7,EDN3,CXCL1,CROT,EPB49,BLK,MBL2,F2 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
