HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | ATP6V1B1,PIKFYVE,ITGB1B.2,ATP6V1AA,MHC2DAB,CLEC4M,TUBA1L2,ACTB,RAC1A,C3A.1 |
| HTLV-I infection | LCK,MAP3K14,PCNA,SLC25A5,EGR1,ATF4,IL15,PRKACB,MAP3K1,MYBL2 |
| Antigen processing and presentation | HLA-DQA1,CANX,B2M,HSPA1A,HLA-DRA,KLRC1,PSME2,PDIA3,TAP1,HLA-C |
| Allograft rejection | IL10,HLA-DQA2,IFNG,H2-AB1,CD86,CD28,GZMB,HLA-E,HLA-A,IL12B |
| Viral carcinogenesis | TRADD,IRF7,KAT2B,TBPL2,PIK3R2,IKBKG,PXN,SNW1,RBPJL,STAT3 |
| ne thyroid disease | HLA-DQA2,IFNA13,TSHR,IFNA10,HLA-DRB1,TSHB,HLA-DMB,CD80,IL4,IFNA1 |
| Type I diabetes mellitus | Il2,HLA-DRB4,H2-AB1,HLA-DRB1,CD86,HLA-B,HLA-DPB1,GAD2,H2-Q10,IL12A |
| Endocytosis | DNM3,SNF8,ADRB2A,CLTCA,SMAP1,RHOA,RAB11FIP3,ARFGAP1,WASH1,HSC70 |
| Graft-versus-host disease | CD80,H2-AB1,HLA-DRB4,CD28,KIR3DL2,KIR3DL1,HLA-E,HLA-DRB1,GZMB,HLA-DRA |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP2 binding | TAP1,TAPBP |
| receptor binding | AGRP2,RSPO3,TNFSF18,LHB,CXCL10,SCP2,GSTK1,NSG1,UTS2,PDGFRB |
| peptide antigen binding | MHC1UJA,MR1,H2-AB1,BF2,HLA-C,MHC1UIA,MHC1UXA2,MHC1UEA,TUBB3,TRGV3 |
| TAP1 binding | TAP2,TAP1,TAPBP |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
