HLA-DQB2

  • Official Full Name

    major histocompatibility complex, class II, DQ beta 2

  • Overview

    HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus.

  • Synonyms

    HLA-DQB2;major histocompatibility complex, class II, DQ beta 2;HLA DXB;HLA class II histocompatibility antigen, DX beta chain;HLA DQB1;OTTHUMP00000029168;OTTHUMP00000029169;OTTHUMP00000178595;OTTHUMP00000178596;major histocompatibility complex, class II, DQ beta 1;DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB);HLA-DXB;HLA-DQB1
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-DQB2-313H Recombinant Human HLA-DQB2 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
HLA-DQB2-4846H Recombinant Human HLA-DQB2 Protein, GST-tagged Wheat Germ Human GST 1-231 a.a.
HLA-DQB2-796HCL Recombinant Human HLA-DQB2 cell lysate Human Non
HLA-DQB2-3599HF Recombinant Full Length Human HLA-DQB2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 231 amino acids
HLA-DQB2-4750H Recombinant Human HLA-DQB2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    HLA-DQB2 involved in several pathways and played different roles in them. We selected most pathways HLA-DQB2 participated on our site, such as Adaptive Immune System,Costimulation by the CD28 family,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Interferon Signaling IFITM2,ARIH1L,FCGR1B,TRIM10,TRIM5,IRF9,ISG20,HERC5,IRF4,BST2
    Interferon gamma signaling GBP2,GBP6,TRIM46,TRIM8,TRIM14,TRIM45,TRIM6,IRF6,FCGR1B,TRIM17
    Immune System CFHL2,WASF2,IFI30,PPAPDC1A,NPEPPS,HERC5,TRIM22,HAVCR2,UBE2U,NLRP4E
    Adaptive Immune System CD200,SIGLEC11,RNF123,DYNC1I2,FRS2A,SH2D1B,CREB1,AP1S1,AGO2,SRMS
    Downstream TCR signaling UBE2V1,TRAT1
    Generation of second messenger molecules GRAP2A,ITK,GRAP2B,EVL
    Cytokine Signaling in Immune system JAK1,HERC5,FRS2A,CNKSR1,PEA15A,DUSP7,SPTBN1,TRIM2,EIF4A1,NEFLB
    Costimulation by the CD28 family CTLA4,MAPKAP1,PDPK1A,BTLA,MAP3K8,CSK,THEM4

    Protein Function

    HLA-DQB2 has several biochemical functions, for example, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQB2 itself. We selected most functions HLA-DQB2 had, and list some proteins which have the same functions with HLA-DQB2. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II receptor activity HLA-DOB,HLA-DOA,HLA-DRB4,HLA-DRB1,HLA-DQA1,HLA-DRB3,HLA-DQA2,HLA-DPA1,HLA-DRA,KRT17

    Interacting Protein

    HLA-DQB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQB2.

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