HIST2H3C

  • Official Full Name

    histone cluster 2, H3c

  • Overview

    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy.

  • Synonyms

    H3;H3.2;H3/M;H3F2;H3FM;H3FN;histone cluster 2, H3c;HIST2H3C
Cat.# Product name Source (Host) Species Tag Protein Length Price
HIST2H3C-114H Recombinant Human HIST2H3C Protein, HIS-tagged E.coli Human HIS
HIST2H3C-4813H Recombinant Human HIST2H3C Protein, GST-tagged Wheat Germ Human GST
HIST2H3C-5890Z Recombinant Zebrafish HIST2H3C Mammalian Cell Zebrafish His
HIST2H3C-5515HCL Recombinant Human HIST2H3C 293 Cell Lysate HEK293 Human Non
HIST2H3C-3603HF Recombinant Full Length Human HIST2H3C Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 136 amino acids

    Involved Pathway

    HIST2H3C involved in several pathways and played different roles in them. We selected most pathways HIST2H3C participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3,Alcoholism,Amyloid formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIST2H3C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amyloid formation TTR,RHBDL1,LTF,ODAM,NAT8,CALCA,TGFBI,SEMG1,HIST4H4,CST3
    Cellular responses to stress POT1,HTATIP,NUPL2,RRAGB,ASF1A,KAT5,CBX6,RRAGA,PRDX3,BMI1B
    Cell cycle CDH1-A,SFN,NIPBLA,MIS18A,HTATIP,SPC25,AURKB,SKA1,STAG1,RAD21
    Cell Cycle, Mitotic BLZF1,NINL,CENPH,KIF18A,LIN52,MCPH1,CEP152,CEP290,NCAPD2,CEP164
    Alcoholism HIST2H3C2,H3F3B,HRAS,CREB3L4,GNB1,HIST1H3G,GRIN2C,MAPK3,HIST1H2BF,FOSB
    Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 HIST4H4,HIST3H2BB,KDM1A,NCOA2,KDM4C
    Cellular Senescence PHC2,CDKN2D,E2F3,RING1,SCMH1,MINK1,HIST4H4,SUZ12A,LMNB1,HIST1H1D
    Chromatin modifying enzymes SMYD2A,KDM4D,PHF17,ING5B,MSL3,KDM5BB,KDM2A,SMARCC1,DPY30,KDM2AA

    Protein Function

    HIST2H3C has several biochemical functions, for example, DNA binding,histone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIST2H3C itself. We selected most functions HIST2H3C had, and list some proteins which have the same functions with HIST2H3C. You can find most of the proteins on our site.

    Function Related Protein
    protein heterodimerization activity EXT1,H2BFWT,BAD,GABPB1,PPP3CB,NR2C2,TLR2,CD3D,DMRT1,HIST1H2BH
    histone binding BRD1,CTSL2,RAG1,CTSL1,PYGO2,CD1d1,ASF1A,NASP,HIST1H4A,HIST1H3G
    DNA binding NKX2.2A,CTCFL,SUPV3L1,FOXF1,DRGX,CREMB,HIST1H2BH,KIF22,NKX6-1,ZNF573
    protein binding BRCA2,SIP1,DYNC1I1,RAI2,SESTD1,MYH8,LSM5,ARAP1,HIST1H4J,TAF1B

    Interacting Protein

    HIST2H3C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIST2H3C here. Most of them are supplied by our site. Hope this information will be useful for your research of HIST2H3C.

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    Resources

    Research Area

    H3 Family

    References

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