HIRIP3
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Official Full Name
HIRA interacting protein 3 -
Overview
The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
HIRIP3;HIRA interacting protein 3;HIRA-interacting protein 3
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- His
- Myc&DDK
- GST
- Non
- His&Fc&Avi
Involved Pathway
HIRIP3 involved in several pathways and played different roles in them. We selected most pathways HIRIP3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HIRIP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HIRIP3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIRIP3 itself. We selected most functions HIRIP3 had, and list some proteins which have the same functions with HIRIP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TRIP13,CCDC64,ACTR8,DDX20,UFL1,PAPOLA,VPS24,FRA10AC1,VDR,IDE |
Interacting Protein
HIRIP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIRIP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIRIP3.
SRPK2;SRPK1;ABCF3;CSNK2A2;TMPO;CSNK2A1;IQCB1
Resources
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References
- Soni, S; Pchelintsev, N; et al. Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for beta-globin gene expression. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:13337-13342(2014).
- Nie, X; Wang, HF; et al. The HIRA complex that deposits the histone H3.3 is conserved in Arabidopsis and facilitates transcriptional dynamics. BIOLOGY OPEN 3:794-802(2014).
