HIRA
-
Official Full Name
histone cell cycle regulator -
Overview
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008] -
Synonyms
HIRA;histone cell cycle regulator;TUP1;DGCR1;TUPLE1;protein HIRA;DiGeorge critical region gene 1;TUP1-like enhancer of split protein 1;HIR histone cell cycle regulation defective homolog A
Recombinant Proteins
- Rhesus macaque
- Human
- Chicken
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
HIRA involved in several pathways and played different roles in them. We selected most pathways HIRA participated on our site, such as Cellular Senescence,Cellular responses to stress,DNA Damage/Telomere Stress Induced Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular Senescence | CBX4,CBX8,HIST4H4,TERF2IP,CDK6,RAD50,BMI1B,RBB4L,KDM6B,TNIK |
| DNA Damage/Telomere Stress Induced Senescence | ACD,ASF1A,HTATIP,POT1,HMGA1-RS1,TERF2IP,POT1A,TINF2,HMGA1B,TERF1 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | HIST1H1D,EP400,H1F0,HMGA1B,HIST1H1A,HIST1H1B,HIST1H1E,ASF1A,HMGA1-RS1,UBN1 |
| Cellular responses to stress | CDKN2B,TXN2,NUP50,H3F3D,RBBP7,HIST1H1D,CHMP4C,RRAGB,HIST1H1B,CDKN2C |
Protein Function
HIRA has several biochemical functions, for example, protein binding,transcription corepressor activity,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIRA itself. We selected most functions HIRA had, and list some proteins which have the same functions with HIRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | SMAD3,TFDP1B,HELT,STAT1B,ELK3,ZNF436,ZNF394,ZNF583,ZNF205,HNF1BB |
| transcription corepressor activity | NR0B2A,PSMC3,HAND1,DRAP1,ZMYND11,SSX4,PRMT5,ATF3,AES,NSD1 |
| protein binding | NAA38,CXorf40A,HPX,KHDC1B,DDRGK1,CRLF3,PRDX4,SEC23A,RRAD,TFDP1 |
Interacting Protein
HIRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIRA here. Most of them are supplied by our site. Hope this information will be useful for your research of HIRA.
H3F3A;Whsc1;UPF1;AIM2;PTBP3;MYC;SNW1;PYHIN1;CDC5L;Cdc26;ASF1A
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