HIPK1
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Official Full Name
homeodomain interacting protein kinase 1 -
Overview
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. -
Synonyms
HIPK1;homeodomain interacting protein kinase 1;homeodomain-interacting protein kinase 1;KIAA0630;MGC26642;MGC33446;MGC33548;Myak;Nbak2;nuclear body-associated kinase 2;nuclear body associated kinase 2b;homeodomain interacting protein kinase 1-l
Recombinant Proteins
- Human
- Mouse
- Sf9 Insect Cell
- Wheat Germ
- Sf21 Insect Cell
- Mammalian Cell
- E.coli
- Insect Cell
- In Vitro Cell Free System
- HEK293
- GST
- His
- His&T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HIPK1-1413H |
Active Recombinant Human HIPK1, GST-tagged
|
Sf9 Insect Cell | Human | GST | 156-555 aa |
|
| HIPK1-4759H | Recombinant Human HIPK1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| HIPK1-516H | Recombinant Human HIPK1, GST-tagged | Sf9 Insect Cell | Human | GST | 156-555 a.a. |
|
| HIPK1-524H | Recombinant Human HIPK1, GST-tagged | Sf21 Insect Cell | Human | GST | 156-555 a.a. |
|
| HIPK1-7636M | Recombinant Mouse HIPK1 Protein | Mammalian Cell | Mouse | His |
|
|
| HIPK1-7858H | Recombinant Human HIPK1 protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Lys290 |
|
| HIPK1-1126H | Recombinant Human HIPK1 Protein (T158-I555), Tag Free | Insect Cell | Human | Non | T158-I555 |
|
| HIPK1-1127H | Recombinant Human HIPK1 Protein (T158-I555), GST tagged | Insect Cell | Human | GST | T158-I555 |
|
| HIPK1-3533HF | Recombinant Full Length Human HIPK1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 1075 amino acids |
|
| HIPK1-4169M | Recombinant Mouse HIPK1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| HIPK1-4169M-B | Recombinant Mouse HIPK1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
HIPK1 involved in several pathways and played different roles in them. We selected most pathways HIPK1 participated on our site, such as Gene Expression,Generic Transcription Pathway,YAP1- and WWTR1 (TAZ)-stimulated gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Generic Transcription Pathway | ZNF2,SKIB,NKX2,CDK8,ZNF688,ZNF726,ZFP30,ZNF285A,ZNF446,USP9 |
| Gene Expression | LAMTOR1,COX16,ZNF573,ADAR,SNRNP25,RPP40,HNRNPH2,SMG9,NR1D2A,GTF3C3 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | TEAD3B,TEAD1A,TBX5A,NKX2,TBX5 |
Protein Function
HIPK1 has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HIPK1 itself. We selected most functions HIPK1 had, and list some proteins which have the same functions with HIPK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | MAP4K6,DCLK2,PAK6,MAP2K6,MAPKAPK5,ATM,PLK3,RIPK3,OXSR1B,STK38 |
| ATP binding | UCK2A,EPHB4B,CLK1,PANK1B,HCK,MAP2K6,TNIKB,NDUFA13,IGF1RB,KIF3C |
| protein binding | LAMTOR2,INPP5A,RBCK1,FOXR2,IQSEC3,ACE2,TRIP10,CALCOCO2,SCAF8,HIST1H4C |
Interacting Protein
HIPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIPK1.
FHL3;TP53;Rassf5;saicar;PKM;Daxx;RASSF5;DAXX;PRPF40A;SKIL;GLUL;UBE2I;SNIP1;ATP13A2;bosutinib;dasatinib
Resources
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References
- Polonio-Vallon, T; Kirkpatrick, J; et al. Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization. CELL CYCLE 13:115-125(2014).
- Zhou, G; Wang, H; et al. p38 MAP Kinase Interacts with and Stabilizes Pancreatic and Duodenal Homeobox-1. CURRENT MOLECULAR MEDICINE 13:377-386(2013).
