HIP1
-
Official Full Name
huntingtin interacting protein 1 -
Overview
The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HIP1;huntingtin interacting protein 1;huntingtin-interacting protein 1;ILWEQ;HIP-I;huntingtin-interacting protein I;MGC126506
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian cells
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- HEK293
- GST
- His
- Non
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HIP1-13782H | Recombinant Human HIP1, GST-tagged | E.coli | Human | GST | 435-764a.a. | |
| Hip1-5638M |
Active Recombinant Mouse Huntingtin Interacting Protein 1, His-tagged
|
Mammalian cells | Mouse | His | 24-678 a.a. |
|
| HIP1-26095TH | Recombinant Human HIP1 | Wheat Germ | Human | Non | 110 amino acids |
|
| HIP1-28314TH | Recombinant Human HIP1 | Wheat Germ | Human | Non | 1037 amino acids |
|
| HIP1-4755H | Recombinant Human HIP1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| HIP1-7597Z | Recombinant Zebrafish HIP1 | Mammalian Cell | Zebrafish | His |
|
|
| HIP1-7634M | Recombinant Mouse HIP1 Protein | Mammalian Cell | Mouse | His |
|
|
| HIP1-788HCL | Recombinant Human HIP1 cell lysate | Human | Non |
|
||
| HIP1-118H | Recombinant Human HIP1 protein, His-tagged | E.coli | Human | His | 435-764 aa |
|
| HIP1-1738H | Recombinant Human HIP1 protein, His & T7-tagged | E.coli | Human | His&T7 | Leu817~Glu1037 (Accession # O00291) |
|
| HIP1-233HF | Recombinant Full Length Human HIP1 Protein | In Vitro Cell Free System | Human | Full L. 1037 amino acids |
|
|
| HIP1-3474HF | Recombinant Full Length Human HIP1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 1037 amino acids |
|
| Hip1-4166M | Recombinant Mouse Hip1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| Hip1-4166M-B | Recombinant Mouse Hip1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
HIP1 involved in several pathways and played different roles in them. We selected most pathways HIP1 participated on our site, such as Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Huntingtons disease | TBPL1,COX6C,COX5B,UQCR11,COX7A2L,REST,COX8C,GRIN2B,ATP5G1,DNAHC8 |
Protein Function
HIP1 has several biochemical functions, for example, actin binding,clathrin binding,phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIP1 itself. We selected most functions HIP1 had, and list some proteins which have the same functions with HIP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ID1,PYDC1,SEC16B,RPL28,CDC37L1,RGS2,PKHD1L1,CAMP,TMEM139,MATN3 |
| phosphatidylinositol binding | RPS6KC1,MTM1,SNX17,FES,SNX1B,WDR35,SNX15,ITPR1,HIP1RB,SNX18B |
| structural constituent of cytoskeleton | KRT16,ACTR2,EPB41L3,TLN2A,KRT71,TUBA2,TUBGCP5,SORBS3,TUBB2B,SYNM |
| clathrin binding | SYT1,SYT1A,SYT5A,SYT7,PICALMB,TOM1,RPH3AL,SYTL3,SYTL4,SYT5B |
| actin binding | MSN,CAP2,SMTNL,MYLK,EPS8L1,CNN2,MYH1B,VPS16,ABRA,WASLB |
Interacting Protein
HIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIP1.
HTT;CLTCL1;CLTC;REL;DAZAP2;AP2A1
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References
- Yan, R; Chen, MX; et al. Glycoprotein lb alpha clustering induces macrophage-mediated platelet clearance in the liver. THROMBOSIS AND HAEMOSTASIS 113:107-117(2015).
- Masuda, T; Sakuma, C; et al. Spatiotemporal patterns of the Huntingtin-interacting protein 1-related gene in the mouse head. CONGENITAL ANOMALIES 53:141-148(2013).
