HHEX
-
Official Full Name
hematopoietically expressed homeobox -
Overview
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008] -
Synonyms
HHEX;hematopoietically expressed homeobox;HEX;PRH;HMPH;PRHX;HOX11L-PEN;hematopoietically-expressed homeobox protein HHEX;homeobox protein HEX;homeobox protein PRH;homeobox, hematopoietically expressed;proline-rich homeodomain-containing transcription factor
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- HEK293T
- In Vitro Cell Free System
- Arg
- His
- Myc&DDK
- GST
- Non
- His&Fc&Avi
Involved Pathway
HHEX involved in several pathways and played different roles in them. We selected most pathways HHEX participated on our site, such as Maturity onset diabetes of the young,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHEX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | CCND2,ZEB1,SIX1,BIRC3,FCGR1,NFKBIZ,PAX5,FCGR1A,IL6,HMGA2 |
| Maturity onset diabetes of the young | INS1,NKX6,ONECUT1,NKX6-1,HES1,PDX1,MNX1,HNF4A,INS,INS2 |
Protein Function
HHEX has several biochemical functions, for example, DNA binding, bending,HMG box domain binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HHEX itself. We selected most functions HHEX had, and list some proteins which have the same functions with HHEX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ZBTB20,HMGA2,HAND1,TFAP2A,CREBBP,ATF3,RELA,HINFP,GZF1,NFE2L3 |
| protein homodimerization activity | ZBTB1,KLRB1B,TP53I3,PLEKHB1,ANXA6,LGALS6,SLC22A6,LSM1,WHRN,ADIPOQ |
| eukaryotic initiation factor 4E binding | EIF4G1,EIF4EBP2,EIF4EBP3L,EIF4EBP1,OTX2,ANGEL1,GRA,DDX3X,LARP1,EIF4EBP3 |
| HMG box domain binding | SP1,HOXC4,CEBPA,GATA3,UTF1,JUN,PAX3,PRRX1,ALX4,MEOX1 |
| protein binding | RTN2,PEX16,SP100,C16orf53,KRTAP10-8,GABBR2,SHC4,AKAP1,TTR,MRAS |
| chromatin binding | SUZ12,PBRM1L,LOXL2,SSBP1,POLG,PHF21A,HDGFRP2,RAG2,CREBBP,KLF14 |
| transcription factor binding | EP300,TRIM6,FOXC1,PPP1R13BA,JUNBB,PIK3R1,UBN1,PSMD10,EGR1,NAB1 |
| repressing transcription factor binding | HDAC7A,TLE4,ARNTL,EIF4E,NOC2L,PRDM5,TBP,SKI,GMNN,SRI |
| sequence-specific DNA binding | FOXM1,GBX1,HOXA6,HOXC5,NR2F6,NFE2,CALCOCO1,SPIC,HOXB9,SOX21A |
Interacting Protein
HHEX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHEX here. Most of them are supplied by our site. Hope this information will be useful for your research of HHEX.
KRTAP10-5;KRTAP10-7;KRTAP10-8;EFEMP2;lysR;KRTAP4-12;TRMT6
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