HHAT

  • Official Full Name

    hedgehog acyltransferase
  • Overview

    Skinny hedgehog (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of hedgehog (see MIM 600725).
  • Synonyms

    HHAT;hedgehog acyltransferase;protein-cysteine N-palmitoyltransferase HHAT;FLJ10724;GUP2;MART 2;MART2;rasp;sit;ski;Skn;2810432O22Rik;AI462858;FLJ34867;AC115917.1;HHAT_HUMAN;MART-2;Melanoma antigen recognized by T cells 2;Melanoma antigen recognized by T-cells 2;MGC11697;OTTMUSP00000033669;Protein cysteine N palmitoyltransferase HHAT;RGD1311746;SKI1;Skinny hedgehog protein 1;Skinny hedgehog protein;OTTHUMP00000034608;OTTHUMP00000034611
Cat.# Product name Source (Host) Species Tag Protein Length Price
HHAT-255H Recombinant Human HHAT Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
HHAT-6488Z Recombinant Zebrafish HHAT Mammalian Cell Zebrafish His
HHAT-7609M Recombinant Mouse HHAT Protein Mammalian Cell Mouse His
Hhat-3389M Recombinant Mouse Hhat Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
HHAT-4149M Recombinant Mouse HHAT Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
HHAT-4149M-B Recombinant Mouse HHAT Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HHAT involved in several pathways and played different roles in them. We selected most pathways HHAT participated on our site, such as Hedgehog ligand biogenesis,Signal Transduction,Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling by Hedgehog SCUBE2,MKS1,CDON,GAS8,IFT52,SPOP,EVC,DISP2,KIF7,BOC
    Hedgehog ligand biogenesis GPC5A,OS9,DISP2,NOTUM1A,SCUBE2,NOTUM,DERL2
    Signal Transduction KAL1A,UCHL5,RLBP1,KTN1,FGD4A,RHPN2,AMOTL2A,RPE65A,APOA4A,SCT

    Protein Function

    HHAT has several biochemical functions, for example, 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity,2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity,2-methylhexanoyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HHAT itself. We selected most functions HHAT had, and list some proteins which have the same functions with HHAT. You can find most of the proteins on our site.

    Function Related Protein
    2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity CML2,DGAT2L6,ACNAT2,NAT14,Acnat1,MBOAT4,MBOAT1,MBOAT7,LPCAT3,CML5
    carnitine O-acyltransferase activity ACNAT2,MBOAT7,DGAT2L6,LPCAT3,CML2,MBOAT4,NAT14,Acnat1,CML5,MBOAT1
    S-acyltransferase activity NAT14,Acnat1,MBOAT4,LPCAT3,CML5,DGAT2L6,MBOAT7,MBOAT1,CML2,ACNAT2
    O-acetyltransferase activity LPCAT3,CML5,DGAT2L6,MBOAT7,ACNAT2,NAT14,MBOAT4,Acnat1,CML2,MBOAT1
    octanoyltransferase activity LIPT2,NAT14,CML5,DGAT2L6,ACNAT2,CML2,LPCAT3,Acnat1,MBOAT7,MBOAT1
    acylglycerol O-acyltransferase activity ACNAT2,CML2,CML5,DGAT2L6,MBOAT7,Acnat1,NAT14,MBOAT4,MBOAT1,LPCAT3
    acyl-CoA N-acyltransferase activity Acnat1,MBOAT1,LPCAT3,MBOAT7,ACNAT2,MBOAT4,CML2,CML5,NAT14,DGAT2L6
    Ras palmitoyltransferase activity ACNAT2,ZDHHC9,CML5,CML2,LPCAT3,DGAT2L6,MBOAT4,NAT14,MBOAT7,MBOAT1
    naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity CML5,DGAT2L6,MBOAT4,NAT14,ACNAT2,MBOAT7,MBOAT1,CML2,LPCAT3,Acnat1

    Interacting Protein

    HHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of HHAT.

    Resources

    Research Area

    Tumor Antigens

    References

    • Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).

    Ask a Question for All HHAT Products

    Required fields are marked with *

    My Review for All HHAT Products

    Required fields are marked with *