HERC6
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Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -
Overview
HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM;179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with;ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange;factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)). -
Synonyms
HERC6;HECT and RLD domain containing E3 ubiquitin protein ligase family member 6;hect domain and RLD 6;probable E3 ubiquitin-protein ligase HERC6;FLJ20637;potential ubiquitin ligase;HECT domain and RCC1-like domain-containing protein 6
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- His
- GST
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HERC6-13741H | Recombinant Human HERC6, His-tagged | E.coli | Human | His | 11-98a.a. | |
| HERC6-4694H | Recombinant Human HERC6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HERC6-7583M | Recombinant Mouse HERC6 Protein | Mammalian Cell | Mouse | His |
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| HERC6-1093H | Recombinant Human HERC6 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Herc6-3385M | Recombinant Mouse Herc6 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| HERC6-4129M | Recombinant Mouse HERC6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HERC6-4129M-B | Recombinant Mouse HERC6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HERC6 involved in several pathways and played different roles in them. We selected most pathways HERC6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HERC6 has several biochemical functions, for example, ligase activity,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC6 itself. We selected most functions HERC6 had, and list some proteins which have the same functions with HERC6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | AMFR,MSL2B,TRIM72,MED23,PDZRN4,TRIM63,PDZRN3B,SYVN1,UHRF1,ARIH1L |
| ligase activity | MKRN3,HECTD1,SMURF2,TTLL5,TTLL2,TRIM32,DTX3,UBE2G1A,DTX3L,TRIM58 |
Interacting Protein
HERC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC6.
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References
- Marfell, BJ; O'Brien, R; et al. Global gene expression profiling of monocyte-derived macrophages from red deer (Cervus elaphus) genotypically resistant or susceptible to Mycobacterium avium subspecies paratuberculosis infection. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 40:210-217(2013).
- Forde, N; Duffy, GB; et al. Evidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau. PHYSIOLOGICAL GENOMICS 44:799-810(2012).
