HEPH
-
Official Full Name
hephaestin -
Overview
This gene encodes a member of the multicopper oxidase protein family. The encoded protein is involved in the transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system, and may be involved in copper transport and homeostasis. In mouse, defects in this gene can lead to severe microcytic anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] -
Synonyms
HEPH;hephaestin;CPL
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- E.coli
- Mammalian cells
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
HEPH involved in several pathways and played different roles in them. We selected most pathways HEPH participated on our site, such as Porphyrin and chlorophyll metabolism,Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEPH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Porphyrin and chlorophyll metabolism | UGT1A1,COX10,UGT1A2,FXN,FECH,MMAB,HCCSB,EARS2,HMBSB,UGT1AB |
| Mineral absorption | MT1G,ATP1B1,MT2,ATP1B3,MT1E,MT1B,STEAP1,MT1M,VDR,SLC26A6 |
Protein Function
HEPH has several biochemical functions, for example, copper ion binding,ferrous iron binding,ferroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HEPH itself. We selected most functions HEPH had, and list some proteins which have the same functions with HEPH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ferrous iron binding | ALKBH3,SERPINB1A,Trf,PLOD1,CDO1,UROD,ISCA1,FXN,ISCA2,ALKBH1 |
| copper ion binding | LOXL2B,POLR1B,ABHD1,F5,TP53,PRNP,ATOX1,LOXL2A,SOD1,LOXL1 |
| ferroxidase activity | HEPHL1,FXN,FTH1,CP,FTMT |
Interacting Protein
HEPH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEPH here. Most of them are supplied by our site. Hope this information will be useful for your research of HEPH.
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