HECW1
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Official Full Name
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -
Synonyms
HECW1;HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1;22195;ENSG00000002746;NEDL1;7p13;KIAA0322;E3 ubiquitin-protein ligase HECW1;E3 ubiquitin-protein ligase HECW1;HECT type E3 ubiquitin ligase;NEDD4-like ubiquitin-protein ligase 1;NEDD4-like E3 ubiquitin-protein ligase 1;HECT, C2 and WW domain-containing protein 1
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HECW1-13728H | Recombinant Human HECW1, His-tagged | E.coli | Human | His | 1-350a.a. | |
| HECW1-2063R | Recombinant Rhesus monkey HECW1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| HECW1-7563M | Recombinant Mouse HECW1 Protein | Mammalian Cell | Mouse | His |
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| HECW1-1884R | Recombinant Rhesus Macaque HECW1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| HECW1-1884R-B | Recombinant Rhesus Macaque HECW1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| HECW1-4114M | Recombinant Mouse HECW1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HECW1-4114M-B | Recombinant Mouse HECW1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HECW1 involved in several pathways and played different roles in them. We selected most pathways HECW1 participated on our site, such as Degradation of DVL,Signal Transduction,Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with HECW1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Wnt | SRY,RNF43,ROR2,PRICKLE1,RSPO1,CDC73,SOX6,ROR1,BCL9,KREMEN2 |
| Degradation of DVL | KLHL12,DVL3,DVL2,HECW1B,DVL1,DACT1 |
| TCF dependent signaling in response to WNT | CDC73,DACT1,LGR6,RSPO4,SOX4A,BCL9L,BCL9,RSPO2,SOX6,LGR4 |
| Signal Transduction | ARHGAP8,ARHGAP6,METAP1,SH2B3,ADM2,RLN1,EFCAB7,LGR5,CRABP2B,RDH12 |
Protein Function
HECW1 has several biochemical functions, for example, ligase activity,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HECW1 itself. We selected most functions HECW1 had, and list some proteins which have the same functions with HECW1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | NEURL3,TRIM11,RBBP6,RAG1,UBE2G2,CDK8,RNF14,MED21,FBXL22,PDZRN4 |
| ligase activity | BRCA1,RNF169,MIB2,UHRF2,HECTD1,PARK2,TRIM63,TRIM69,TRIM28,PIAS3 |
Interacting Protein
HECW1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HECW1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HECW1.
FBXL15;CACNA1A;GFI1B;USP7;MPHOSPH8
Resources
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References
- Zhi, X; Chen, CS; et al. WWP1: a versatile ubiquitin E3 ligase in signaling and diseases. CELLULAR AND MOLECULAR LIFE SCIENCES 69:1425-1434(2012).
- Li, Y; Zhou, Z; et al. WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer. ONCOGENE 28:2948-2958(2009).
