HCN1
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Official Full Name
hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 -
Overview
HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 proteins play an important role for motor learning and synapse formation through integration of cerebellar Purkinje cells. The two proteins also shape autonomous activity of single neurons and the periodicity of network oscillations. HCN1 expression is particularly high in the cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. Hyperpolarization of activated cation channels of the HCN gene family such as HCN1, contributes to spontaneous rhythmic activity in both heart and brain. HCN channels pass both Na+ and K+ with relative permeability ratio of ~0.15 to 0.25. The primary sequence of HCN pore region is clearly related to that of highly selective K+ channels. In contrast to nonselective CNG or Na+-channels, both K+ and HCN channels contain a GYG motif in the pore. -
Synonyms
HCN1;hyperpolarization-activated cyclic nucleotide-gated potassium channel 1;potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Recombinant Proteins
- Rat
- Mouse
- Human
- Mammalian Cell
- HEK293
- His
- His&Flag
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HCN1-2806R | Recombinant Rat HCN1 Protein | Mammalian Cell | Rat | His |
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| HCN1-7519M | Recombinant Mouse HCN1 Protein | Mammalian Cell | Mouse | His |
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| HCN1-1180HFL | Recombinant Human HCN1 protein, His&Flag-tagged | HEK293 | Human | His&Flag | Full L. |
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| HCN1-2461R | Recombinant Rat HCN1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| HCN1-2461R-B | Recombinant Rat HCN1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| HCN1-4082M | Recombinant Mouse HCN1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HCN1-4082M-B | Recombinant Mouse HCN1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HCN1 involved in several pathways and played different roles in them. We selected most pathways HCN1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HCN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
HCN1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by HCN1 itself. We selected most functions HCN1 had, and list some proteins which have the same functions with HCN1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
HCN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HCN1.
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References
- Herrmann, S; Layh, B; et al. Novel insights into the distribution of cardiac HCN channels: An expression study in the mouse heart. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 51:997-1006(2011).
- Stradleigh, TW; Ogata, G; et al. Colocalization of Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channel Subunits in Rat Retinal Ganglion Cells. JOURNAL OF COMPARATIVE NEUROLOGY 519:2546-2573(2011).
