HAT1
-
Official Full Name
histone acetyltransferase 1 -
Overview
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. -
Synonyms
HAT1;histone acetyltransferase 1;histone acetyltransferase type B catalytic subunit;KAT1;HAT 1;HAT1_HUMAN;Histidine aminotransferase 1;OTTHUMP00000163124
Recombinant Proteins
- Zebrafish
- Mouse
- Rat
- Human
- Chicken
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- His&T7
- GST
- Non
- His&Fc&Avi
Involved Pathway
HAT1 involved in several pathways and played different roles in them. We selected most pathways HAT1 participated on our site, such as Alcoholism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alcoholism | HIST1H4G,HIST1H4J,HIST3H2BB-PS,GNG5,HIST2H2BE,NTRK2,HIST2H3A,PPP1CA,HIST1H2BD,PPP1CB |
Protein Function
HAT1 has several biochemical functions, for example, H4 histone acetyltransferase activity,histone acetyltransferase activity,histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAT1 itself. We selected most functions HAT1 had, and list some proteins which have the same functions with HAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| H4 histone acetyltransferase activity | NAA50,NAT15,NAA60,BRCA2,ELP3 |
| protein binding | SLC1A1,NDOR1,KATNBL1,DNAJC11,TCTE3,IL28RA,BRD2,TUBB2B,SLX4,MPZL2B |
| histone binding | ANP32B,SMARCA4A,NPM2,HJURP,TBL1XR1,HIST4H4,HIST2H4A,SMARCA2,JAK2,BRDT |
| histone acetyltransferase activity | GTF3C4,KAT6A,NCOA2,KAT2B,KAT6B,NCOA1,KAT5,vnc,ATF2,KAT7B |
Interacting Protein
HAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAT1.
MEOX2;vpr;TCF4;REL;RBBP4;TNFAIP1;HIST1H3D
HAT1 Related Signal Pathway
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