HAS1
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Official Full Name
hyaluronan synthase 1 -
Overview
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. -
Synonyms
HA synthase 1;HAS;HAS1;HAS1_HUMAN;HuHAS1;Hyaluronan synthase 1;Hyaluronate synthase 1;Hyaluronic acid synthase 1
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Western clawed frog
- Mus musculus
- Xenopus laevis
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- E.coli
- S. cerevisiae
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- N-His&C-Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HAS1-3527H | Recombinant Human HAS1 protein, His-tagged | E.coli | Human | His | 74-401 aa | |
| Has1-426R | Recombinant Rat Has1 protein, His-tagged | S. cerevisiae | Rat | His | Met1~Val583 |
|
| HAS1-4583H | Recombinant Human HAS1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| HAS1-7572Z | Recombinant Zebrafish HAS1 | Mammalian Cell | Zebrafish | His |
|
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| Has1-7852R | Recombinant Rat Has1 protein, His-tagged | E.coli | Rat | His | Tyr164~Ala421 |
|
| HAS1-2229H | Recombinant Human HAS1 Protein, His-tagged | E.coli | Human | His | Tyr160-Ala416 |
|
| HAS1-3483HF | Recombinant Full Length Human HAS1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 577 amino acids |
|
| has1-5433W | Recombinant Western clawed frog has1 protein, His&Myc-tagged | E.coli | Western clawed frog | N-His&C-Myc | 82-401aa |
|
| RFL19950MF | Recombinant Full Length Mouse Hyaluronan Synthase 1(Has1) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-583) |
|
| RFL23710XF | Recombinant Full Length Xenopus Laevis Hyaluronan Synthase 1(Has1) Protein, His-Tagged | E.coli expression system | Xenopus laevis | His | Full L. Full Length (1-588) |
|
| RFL24824XF | Recombinant Full Length Xenopus Tropicalis Hyaluronan Synthase 1(Has1) Protein, His-Tagged | E.coli expression system | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | His | Full L. Full Length (1-590) |
|
| RFL28343HF | Recombinant Full Length Human Hyaluronan Synthase 1(Has1) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-578) |
|
Involved Pathway
HAS1 involved in several pathways and played different roles in them. We selected most pathways HAS1 participated on our site, such as Glycosaminoglycan metabolism,Hyaluronan biosynthesis and export,Hyaluronan metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of carbohydrates | MAPK1IP1L,SLC25A11,TREH,B3GNT2,HAS3,OMD,SLC25A1,GCKR,SLC2A3,B3GNT2A |
| Glycosaminoglycan metabolism | GPC1B,CHP,SLC35B3,SLC26A1,MAPK1IP1L,KERA,UST,ST3GAL3A,LYVE1,Gpc2 |
| Hyaluronan metabolism | LYVE1,CHP,KIAA1199,STAB2,HAS3 |
| Metabolism | DPYDA.1,NOSIP,NEU4,Agmo,ACMSD,NFYBA,CDK19,AK8,ATP5L,KCNS3A |
| Hyaluronan biosynthesis and export | HAS3,KIAA1199 |
Protein Function
HAS1 has several biochemical functions, for example, hyaluronan synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HAS1 itself. We selected most functions HAS1 had, and list some proteins which have the same functions with HAS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hyaluronan synthase activity | HAS3,HYAL1,HAS2 |
Interacting Protein
HAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAS1.
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References
- Muller, J; Gorressen, S; et al. Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction. BASIC RESEARCH IN CARDIOLOGY 109:-(2014).
- Torronen, K; Nikunen, K; et al. Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes. HISTOCHEMISTRY AND CELL BIOLOGY 141:17-31(2014).
