HAGH
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Official Full Name
hydroxyacylglutathione hydrolase -
Overview
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HAGH;hydroxyacylglutathione hydrolase;hydroxyacyl glutathione hydrolase;hydroxyacylglutathione hydrolase, mitochondrial;GLO2;GLXII;HAGH1;GLX II;Glyoxalase II;OTTHUMP00000158839;OTTHUMP00000158840;hydroxyacylglutathione hydroxylase;GLX2
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
HAGH involved in several pathways and played different roles in them. We selected most pathways HAGH participated on our site, such as Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAGH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyruvate metabolism | ALDH9A1A.1,PDP1,PDPR,GRHPR,DLDH,PDK3B,hchA,ALDH9A1,PCXB,PDHA2 |
Protein Function
HAGH has several biochemical functions, for example, hydroxyacylglutathione hydrolase activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAGH itself. We selected most functions HAGH had, and list some proteins which have the same functions with HAGH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FGF19,NCBP1,NEURL1B,DDA1,KCNE4,GUCY1B3,PLAUR,ASPH,ZEB1,NHLH2 |
| metal ion binding | FTR54,PICK1,TRIM101,TRIM35-27,ZFP653,AOC1,ZNF18,CPEB1,ZFP704,NME6 |
| hydroxyacylglutathione hydrolase activity | PNKD |
Interacting Protein
HAGH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAGH here. Most of them are supplied by our site. Hope this information will be useful for your research of HAGH.
TERF2IP;BST2
Resources
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References
- Kovac, J; Podkrajsek, KT; et al. Weak association of glyoxalase 1 (GLO1) variants with autism spectrum disorder. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY 24:75-82(2015).
- Rabbani, N; Xue, MZ; et al. Activity, regulation, copy number and function in the glyoxalase system. BIOCHEMICAL SOCIETY TRANSACTIONS 42:419-424(2014).
