HADHB
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Official Full Name
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -
Overview
This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. Mutations in this gene result in trifunctional protein deficiency. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Alternatively spliced transcript variants have been found; however, their full-length nature is not known. -
Synonyms
HADHB;hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit;hydroxyacyl Coenzyme A dehydrogenase/3 ketoacyl Coenzyme A thiolase/enoyl Coenzyme A hydratase (trifunctional protein), beta subunit;trifunctional enzyme subunit beta, mitochondrial;mitochondrial trifunctional protein;beta subunit;MTPB;2 enoyl Coenzyme A (CoA) hydratase beta subunit;3 ketoacyl Coenzyme A (CoA) thiolase of mitochondrial trifunctional protein beta subunit;3 ketoacyl Coenzyme A thiolase;3 ketoacyl Coenzyme A thiolase of mitochondrial trifunctional protein beta subunit;3-ketoacyl-CoA thiolase;Acetyl CoA acyltransferase;Acetyl-CoA acyltransferase;Beta ketothiolase;Beta-ketothiolase;ECHB;ECHB_HUMAN;HADH;Hydroxyacyl Coenzyme A (CoA) dehydrogenase beta subunit;Hydroxyacyl Coenzyme A dehydrogenase;Hydroxyacyl Coenzyme A dehydrogenase beta subunit;Hydroxyacyl Coenzyme A dehydrogenase/3 ketoacyl Coenzyme A thiolase/enoyl Coenzyme A hydratase (trifunctional protein) beta subunit;MGC87480;Mitochondrial trifunctional enzyme beta subunit;Mitochondrial trifunctional protein beta subunit;MS733;MSTP 029;MSTP029;TP beta;TP-beta;TPbeta;Trifunctional enzyme subunit beta;Trifunctional enzyme subunit beta mitochondrial;Trifunctional protein;OTTHUMP00000122456;OTTHUMP00000200808;2-enoyl-Coenzyme A (CoA) hydratase, beta subunit;mitochondrial trifunctional enzyme, beta subunit;mitochondrial trifunction
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&T7
- His&Fc&Avi
- His&Myc
Involved Pathway
HADHB involved in several pathways and played different roles in them. We selected most pathways HADHB participated on our site, such as Fatty acid elongation,Fatty acid degradation,Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HADHB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | LPCAT1,PLA2G4A,POLR2A,PDHB,HKDC1,HSD17B3,PLA2G3,CCBL1,LASS1,UCK2A |
| Valine, leucine and isoleucine degradation | AOX2P,HIBADHB,ACAA1A,HADHAA,MCEE,BCKDHA,HIBADH,ACADSB,HMGCS2,HADHA |
| Fatty acid degradation | ALDH7A1,CYP4A14,ACADSB,ACAT2,ECI2,ADH2-1,ACSL1A,ADH4,ALDH3A2A,ACAT1 |
| Fatty acid metabolism | HSD17B12,ACSL3A,PTPLAD1,ACAA2,PTPLAD2,TECR,ELOVL6,CPT1A,HADHAA,ACADL |
| Fatty acid elongation | HSD17B12A,PPT1,PTPLA,PPT2,ELOVL2,HADHAA,ELOVL1B,ELOVL4B,ACOT5,HADH |
Protein Function
HADHB has several biochemical functions, for example, 3-hydroxyacyl-CoA dehydrogenase activity,acetyl-CoA C-acyltransferase activity,enoyl-CoA hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HADHB itself. We selected most functions HADHB had, and list some proteins which have the same functions with HADHB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enoyl-CoA hydratase activity | ECHS1,HADHAA,HADHAB,EHHADH,HADHA,AUH |
| poly(A) RNA binding | MBNL2,ETF1A,NHP2L1,ZFP598,CNBP,RBM25,REXO4,MRPL37,RBM19,ZC3H15 |
| 3-hydroxyacyl-CoA dehydrogenase activity | EHHADH,HADH,H2-KE6,HADHA,HADHAA,HSD17B4,HSD17B8,HSD17B10,HADHAB |
| acetyl-CoA C-acyltransferase activity | ACAA2,ACAA1,ACAA1A |
| protein binding | CACFD1,RBMX,TFAM,CENPI,CACNB4,ALDH3A1,TBP,CIT,COG2,RYR1 |
| long-chain-3-hydroxyacyl-CoA dehydrogenase activity | HADHA |
Interacting Protein
HADHB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HADHB here. Most of them are supplied by our site. Hope this information will be useful for your research of HADHB.
MYC;GABARAPL1;GABARAPL2;MAP1LC3B;MAP1LC3A;vpu
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