H2-Aa
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Official Full Name
histocompatibility 2, class II antigen A, alpha -
Synonyms
H2-AA;histocompatibility 2, class II antigen A, alpha;ENSMUSG00000036594;Ia1;H2Aa;Ia-1;H-2Aa;Aalpha;IAalpha;I-Aalpha;17 B1;17 18.65 cM;histocompatibility 2, class II antigen A, alpha;histocompatibility 2, class II antigen A, alpha;A alpha;MHC-II I-A(d) alpha;MHC class II antigen;major histocompatibility protein class II alpha chain;H-2 class II histocompatibility antigen, A-B alpha chain;H-2 class II histocompatibility antigen, A-F alpha chain;H-2 class II histocompatibility antigen, A-K alpha chain;H-2 class II histocompatibility antigen, A-Q alpha chain;H-2 class II histocompatibility antigen, A-R alpha chain;H-2 class II histocompatibility antigen, A-S alpha chain;H-2 class II histocompatibility antigen, A-U alpha chain
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| H2-AA-7424M | Recombinant Mouse H2-AA Protein | Mammalian Cell | Mouse | His |
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| H2-Aa-1084M | Recombinant Mouse H2-Aa Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| H2-AA-4038M | Recombinant Mouse H2-AA Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| H2-AA-4038M-B | Recombinant Mouse H2-AA Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
H2-Aa involved in several pathways and played different roles in them. We selected most pathways H2-Aa participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with H2-Aa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Intestinal i | CD80,IL15,HLA-DRB4,CCL27B,HLA-DMB,MHC2DAB,AICDA,HLA-DRB5,Icosl,CXCL12 |
| Inflammatory bowel disease (IBD) | H2-AB1,TLR2,IL23R,HLA-DQA1,RORC,GATA3,HLA-DRA,TGFB3,TLR5,Il23a; Il12b |
| Antigen processing and presentation | HLA-DRB5,CALR,CTSB,CD8B,H2-AB1,KLRD1,HLA-DRB1,KIR3DL1,HSPA5,HLA-DQA1 |
| Asthma | HLA-DRB3,H2-AB1,PRG2,HLA-DQB1,CD40LG,HLA-DMA,IL13,CCL11,HLA-DRB1,HLA-DRA |
| Leishmaniasis | IRAK4,IL12B,HLA-DOA,TAB2,NCF1,IRAK1,MAP3K7,ITGB1,HLA-DOB,NCF4 |
| Allograft rejection | HLA-DQA1,Fasl,MICA,H2-AB1,HLA-DRB4,CD80,CD28,GZMB,CD86,IL4 |
| Systemic lupus erythematosus | HIST1H4J,HIST2H4A,HIST1H4N,SNRPD1,HIST1H2AL,HIST1H2BF,FCGR4,HIST1H3I,HIST1H3E,C1RA |
| Influenza A | TNFRSF10B,MAPK9,RELA,TNFRSF10C,MAPK12,Fasl,DNAJB1,CCL5,IL6,IFNA3 |
| HTLV-I infection | IL1R1,CD40,TGFB2,FZD8,DVL1,VAC14,EGR2,TP53INP1,MRAS,CCND3 |
Protein Function
H2-Aa has several biochemical functions, for example, peptide antigen binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by H2-Aa itself. We selected most functions H2-Aa had, and list some proteins which have the same functions with H2-Aa. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | DHCR24,TRGV3,MHC1UFA,BF2,MHC1UEA,HLA-DRB1,MHC1UKA,MHC1ZKA,HLA-F,HLA-DRB3 |
| protein binding | CC10,C1orf187,RORC,PCTP,UBXN6,SERPINF2,FOXRED2,ADAM17,RAMP3,PLAU |
| protein heterodimerization activity | GTF2A2,DRD1,PRMT8,SYT14,TIMELESS,H2AFB3,MICU1,HIST1H3D,HIST1H2AF,TCF3 |
Interacting Protein
H2-Aa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H2-Aa here. Most of them are supplied by our site. Hope this information will be useful for your research of H2-Aa.
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References
- Zemelka-Wiacek, M; Szczepanik, M; et al. Tc1-mediated contact sensitivity reaction, its mechanism and regulation. POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ 68:955-969(2014).
- Schwaiger, J; Aberle, JH; et al. Specificities of Human CD4(+) T Cell Responses to an Inactivated Flavivirus Vaccine and Infection: Correlation with Structure and Epitope Prediction. JOURNAL OF VIROLOGY 88:7828-7842(2014).
