Galectin-3
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Official Full Name
Galectin-3 -
Overview
Galectin-3 is a galactose-specific lectin which binds IgE. This lectin may mediate with the alpha-3, beta-1 integrin for the stimulation by CSPG4 of endothelial cells migration. Found together with DMBT1, which is required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus, it acts as a pre-mRNA splicing factor. Galectin-3 is involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. It probably forms homo- or heterodimers. Additionally, galectin-3 interacts with DMBT1. This lectin forms a complex with ITGA3, ITGB1 and CSPG4. It also interacts with LGALS3BP, LYPD3, CYHR1 and UACA. It is highly expressed in the colonic epithelium and abundant in activated macrophages. -
Synonyms
LGALS3;CBP35;GAL3;GALBP;GALIG;L31;LGALS2;MAC2;35 kDa lectin;IgE-binding protein;MAC-2 antigen;carbohydrate-binding protein 35;galactose-specific lectin 3;laminin-binding protein;lectin L-29
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Involved Pathway
Galectin-3 involved in several pathways and played different roles in them. We selected most pathways Galectin-3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Galectin-3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
Galectin-3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Galectin-3 itself. We selected most functions Galectin-3 had, and list some proteins which have the same functions with Galectin-3. You can find most of the proteins on our site.
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Interacting Protein
Galectin-3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Galectin-3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Galectin-3.
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