GTSE1
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Official Full Name
G-2 and S-phase expressed 1 -
Overview
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. -
Synonyms
GTSE1;G-2 and S-phase expressed 1;G2 and S phase-expressed protein 1;B99;GTSE 1;B99 homolog;G 2 and S phase expressed 1;G two S phase expressed protein 1;protein B99 homolog
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GTSE1-2800Z | Recombinant Zebrafish GTSE1 | Mammalian Cells | Zebrafish | His |
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| GTSE1-2986C | Recombinant Chicken GTSE1 | Mammalian Cells | Chicken | His |
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| GTSE1-4479H | Recombinant Human GTSE1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GTSE1-5680HCL | Recombinant Human GTSE1 293 Cell Lysate | HEK293 | Human | Non |
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| GTSE1-3338HF | Recombinant Full Length Human GTSE1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 720 amino acids |
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Involved Pathway
GTSE1 involved in several pathways and played different roles in them. We selected most pathways GTSE1 participated on our site, such as p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GTSE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p signaling pathway | TP53AIP1,PMAIP1,BAXA,PERP,CASP9,ZMAT3,RCHY1,FAS,CASP8,IGFBP3 |
Protein Function
GTSE1 has several biochemical functions, for example, molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GTSE1 itself. We selected most functions GTSE1 had, and list some proteins which have the same functions with GTSE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | MUC6,FBXL16,SKINT1,GM2506,DESI1A,BCORL1,CCDC160,SDR16C6,MYOZ2A,GNB1L |
| protein binding | SUPT6H,EDN1,NOXO1,HIST1H1E,XAGE3,CXCL2,DZIP1L,C16orf53,RFC5,EIF3E |
Interacting Protein
GTSE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTSE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GTSE1.
PLK1;USP11;HIP1;SEC23A;Sec24c;PICALM;SEC16A;SYNJ1;HIP1;PIK3C2A;GAK;SEC16A;SEC16A;N4BP3
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References
- Munzer, DGG; Kostoglou, M; et al. Developing a cyclin blueprint as a tool for mapping the cell cycle in GS-NSO. BIOCHEMICAL ENGINEERING JOURNAL 81:97-107(2013).
- Kastner, S; Voss, T; et al. Expression of G Protein-Coupled Receptor 19 in Human Lung Cancer Cells Is Triggered by Entry into S-Phase and Supports G(2)-M Cell-Cycle Progression. MOLECULAR CANCER RESEARCH 10:1343-1358(2012).
