GTPBP4
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Official Full Name
GTP binding protein 4 -
Overview
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. Active in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. -
Synonyms
GTPBP4;GTP binding protein 4;nucleolar GTP-binding protein 1;GTP binding protein;CRFG;FLJ10686;FLJ10690;G protein binding protein CRFG;NGB;NOG1;Chronic renal failure gene protein;Nucleolar GTP binding protein 1;OTTHUMP00000018953;GTP-binding protein NGB;G protein-binding protein CRFG
Recombinant Proteins
- Zebrafish
- Chicken
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GTPBP4-10224Z | Recombinant Zebrafish GTPBP4 | Mammalian Cell | Zebrafish | His |
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| GTPBP4-1498C | Recombinant Chicken GTPBP4 | Mammalian Cell | Chicken | His |
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| GTPBP4-4474H | Recombinant Human GTPBP4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GTPBP4-7376M | Recombinant Mouse GTPBP4 Protein | Mammalian Cell | Mouse | His |
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| GTPBP4-5684HCL | Recombinant Human GTPBP4 293 Cell Lysate | HEK293 | Human | Non |
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| GTPBP4-3425HF | Recombinant Full Length Human GTPBP4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 634 amino acids |
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| GTPBP4-4002M | Recombinant Mouse GTPBP4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GTPBP4-4002M-B | Recombinant Mouse GTPBP4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GTPBP4 involved in several pathways and played different roles in them. We selected most pathways GTPBP4 participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with GTPBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome biogenesis in eukaryotes | EIF6,RPP38,BMS1,UTP15,DKC1,RCL1,UTP18,IMP3,WDR3,GAR1 |
Protein Function
GTPBP4 has several biochemical functions, for example, GTP binding,GTPase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GTPBP4 itself. We selected most functions GTPBP4 had, and list some proteins which have the same functions with GTPBP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activity | DNM1L,TUBA8L4,RAB39BA,MFN2,GNB3,RAB8B,RRAGD,RAB15,GNG3,GNA11 |
| GTP binding | GMPPB,RAB35B,GIMAP7,EEF1A1A,RAB44,GTPBP6,SUCLG1,EHD1A,SUCLG2,EFTUD1 |
| protein binding | C4BPA,SERTAD1,TA,HDAC3,GLI2,NAGK,TEX14,CCS,B9D2,UPRT |
| poly(A) RNA binding | HNRNPR,BCLAF1,YARS,PTCD1,ZNF346,EIF3G,EBI3,KIAA1429,CKAP4,CCT3 |
Interacting Protein
GTPBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTPBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GTPBP4.
NF2;ESR1;gtp;guanosine 5'-[gamma-thio]triphosphate;EIF6;PINX1;LYAR;ssrna_ug;Srp72;NOP56
Resources
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References
- Tong, JHM; Lung, RWM; et al. Characterization of rare transforming KRAS mutations in sporadic colorectal cancer. CANCER BIOLOGY & THERAPY 15:768-776(2014).
- Feliszek, M; Speckmann, V; et al. A search for functional histamine H-4 receptors in the human, guinea pig and mouse brain. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 388:11-17(2015).
