GTF2IRD2
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Official Full Name
GTF2I repeat domain containing 2 -
Overview
This gene is unusual in that its coding sequence is mostly derived from Charlie8 repeat elements. However, there is mRNA and EST evidence to suggest that this gene is transcribed, and the encoded protein has a homolog in mouse, with which it shares 78% sequence identity. The exact function of this gene product is not known. It is inferred to be a transcription factor based on the presence of GTF2I-like repeats (containing helix-loop-helix motifs), also found in other proteins such as GTF2IRD1 and GTF2I. These three genes are clustered together on chr 7q11.23. -
Synonyms
GTF2IRD2;GTF2I repeat domain containing 2;general transcription factor II-I repeat domain-containing protein 2A;FLJ37938;GTF2IRD2A;transcription factor GTF2IRD2;FLJ21423;FP630;general transcription factor II i repeat domain 2 alpha;general transcription factor II I repeat domain-containing protein 2A;GTF2I repeat domain containing protein 2A;GTF2IRD2 alpha;MGC75203;Transcription factor GTF2IRD2 alpha;transcription factor GTF2IRD2-alpha;GTF2I repeat domain-containing protein 2A
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GTF2IRD2-4460H | Recombinant Human GTF2IRD2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GTF2IRD2-7365M | Recombinant Mouse GTF2IRD2 Protein | Mammalian Cell | Mouse | His |
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| GTF2IRD2-764HCL | Recombinant Human GTF2IRD2 cell lysate | Human | Non |
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| GTF2IRD2-3408HF | Recombinant Full Length Human GTF2IRD2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 498 amino acids |
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| GTF2IRD2-3995M | Recombinant Mouse GTF2IRD2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GTF2IRD2-3995M-B | Recombinant Mouse GTF2IRD2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GTF2IRD2 involved in several pathways and played different roles in them. We selected most pathways GTF2IRD2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GTF2IRD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
GTF2IRD2 has several biochemical functions, for example, DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GTF2IRD2 itself. We selected most functions GTF2IRD2 had, and list some proteins which have the same functions with GTF2IRD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SIRPB1,TSSC4,MUL1,CA1,STX7,RPL23,ZBTB43,TA,RUNX1T1,PDE6G |
| DNA binding | SPI1B,DHX9,SOX8,SIX9,ZBED1,SOX12,NR1I3,ZNF146,NPAS4A,DDIT3 |
Interacting Protein
GTF2IRD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTF2IRD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GTF2IRD2.
TRIM54;HSP90AB1;MLF1;PSMD2;CDC37;q53fc7_human;Hacd3;q96be0_human;AARSD1
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References
- Gunbin, KV; Ruvinsky, A; et al. Evolution of General Transcription Factors. JOURNAL OF MOLECULAR EVOLUTION 76:28-47(2013).
- Palmer, SJ; Taylor, KM; et al. GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members. JOURNAL OF CELL SCIENCE 125:5040-5050(2012).
