GTF2H2
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Official Full Name
general transcription factor IIH, polypeptide 2, 44kDa -
Overview
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. -
Synonyms
GTF2H2;general transcription factor IIH, polypeptide 2, 44kDa;general transcription factor IIH, polypeptide 2 (44kD subunit);general transcription factor IIH subunit 2;BTF2;BTF2P44;T BTF2P44;TFIIH;MGC102806;Basic transcription factor 2 44 kDa subunit;General transcription factor IIH;BTF2 p44;OTTHUMP00000223559;OTTHUMP00000223561;OTTHUMP00000224504;general transcription factor IIH polypeptide 2;TFIIH basal transcription factor complex p44 subunit;ge;T-BTF2P44
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
GTF2H2 involved in several pathways and played different roles in them. We selected most pathways GTF2H2 participated on our site, such as Basal transcription factors,Nucleotide excision repair,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GTF2H2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | COPS2,LIG1,INO80E,MNAT1,CUL4A,ERCC6,ACTR5,GTF2H2C_2,XPA,KIAA1530 |
| Viral carcinogenesis | C3,PXN,GTF2H4,YWHAE,HIST1H2BD,PKM,SND1,SCIN,RAC1,HLA-G |
| Basal transcription factors | TAF3,MNAT1,TAF6L,GTF2B,TAF7L,GTF2A1,GTF2H3,CDK7,TAF10,GTF2I |
Protein Function
GTF2H2 has several biochemical functions, for example, contributes_to DNA-dependent ATPase activity,contributes_to RNA polymerase II carboxy-terminal domain kinase activity,nucleic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GTF2H2 itself. We selected most functions GTF2H2 had, and list some proteins which have the same functions with GTF2H2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | GATA2,ZFP13,AHRRB,CSRNP1,ZNF155,HNF4A,KLF9,HOXC5A,NFIL3-3,MYOG |
| protein N-terminus binding | MEN1,ACOX1,ERCC3,PEX14,MORF4L1,DCN,MECP2,GLRX,SLC6A3,RND2 |
| contributes_to DNA-dependent ATPase activity | GTF2H3,ERCC2,ERCC3,GTF2H4,MNAT1,RBBP4,BPTF,GTF2H1 |
| contributes_to RNA polymerase II carboxy-terminal domain kinase activity | ERCC3,ERCC2,GTF2H3,GTF2H4,MNAT1,GTF2H1 |
| translation factor activity, RNA binding | SOX11,EIF4G3,CPEB1,CPEB1A,EEF1A2,EEF2K,GTF2H3,EIF4H,ABCF1,EIF4A1 |
| nucleic acid binding | INSM1A,ZSCAN2,ALYREF,SP7,ZFP629,ARPP21,GFI1AB,CELF5A,POLN,ZFP503 |
| zinc ion binding | LIMD1,SHRPRBCK1R,ABLIM1B,BAZ1A,ADA,RYBP,TRIM41,LHX2B,CPA4,ENPP1 |
| contributes_to protein kinase activity | ERCC2,GTF2H4,GTF2H3,ERCC3,GTF2H1 |
| protein binding | WIPF1,HSPA13,LRRC4C,LGALS14,PLA2G16,NPEPL1,EYA3,PACSIN2,NDOR1,ATXN7L1 |
Interacting Protein
GTF2H2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTF2H2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GTF2H2.
ERCC8;GTF2H1;phoA;CDK7;GTF2H5
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