GSTM3
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Official Full Name
glutathione S-transferase mu 3 (brain) -
Overview
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. -
Synonyms
GSTM3;glutathione S-transferase mu 3 (brain);glutathione S transferase M3 (brain);glutathione S-transferase Mu 3;GST5;brain GST;brain type mu glutathione S transferase;glutathione S alkyltransferase M3;glutathione S aryltransferase M3;glutathione S transferase M3;Glutathione S transferase Mu 3;glutathione S transferase, Mu 3;GST class mu 3;GST class-mu 3;GSTB;GSTM3-3;GSTM3_HUMAN;GTM3;hGSTM3-3;MGC3310;MGC3704;S (hydroxyalkyl)glutathione lyase M3;glutathione S-transferase, Mu-3;glutathione S-aryltransferase M3;glutathione S-alkyltransferase M3;glutathione S-aralkyltransferase M3;S-(hydroxyalkyl)glutathione lyase M3;glutathione S-transferase M3 (brain);brain type mu-glutathione S-transferase
Recombinant Proteins
- Human
- Rhesus macaque
- Cynomolgus
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
GSTM3 involved in several pathways and played different roles in them. We selected most pathways GSTM3 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | ADH1C,CYP1A1,ALDH3B1,UGT2B7,UGT1A6B,UGT1A2,GSTA3,GSTM1,ADH7,ADH6 |
| Glutathione metabolism | GPX4B,G6PDX,TXNDC12,GGT1A,RRM1,GPX7,GPX8,MGST1.1,GGT1,RRM2 |
| Drug metabolism - cytochrome P | UGT2A1,ALDH3B2,FMO6P,GSTT1,UGT5G1,ALDH1A3,GSTA3,AOX4,MAOB,MGST1.1 |
| Metabolism of xenobiotics by cytochrome P | UGT1A7,GSTO1,UGT1A7C,ALDH1A3,UGT2B7,MGST2,AKR7A2,AKR7A3,MGST1.2,CBR3 |
Protein Function
GSTM3 has several biochemical functions, for example, enzyme binding,glutathione binding,glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTM3 itself. We selected most functions GSTM3 had, and list some proteins which have the same functions with GSTM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione binding | GSTM4,PTGES,GSTM7,LTC4S,PTGES2,MGST1,GSS,GPX1,PTGESL,GSTP2 |
| glutathione transferase activity | GSTO2,GSTP1,GSTA,LTC4S,GSTA3,EEF1G,MGST1,GSTAL,GSTK1,GSTT4 |
| protein homodimerization activity | GALE,RENBP,MFF,SERPINF2,UGT1A3,MAOB,RRAGA,CRYBA1,DROSHA,PVRL1A |
| identical protein binding | DYNLT1,SLK,PRMT1,ALS2CL,PFKFB1,PON2,KCNJ10,FHOD1,LTBR,GOT2B |
| enzyme binding | PUS7,PPARG,BCR,PIAS1,SCNM1-PS,ATXN10,CBS,PAWR,HSPA5,CYP2C8 |
Interacting Protein
GSTM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTM3.
GH1;TFE3;MPG;HLA-C;PAK2;ATG5;TRAF6;SH3GL2;GRB2;RBL2
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References
- Nishimura, J; Dewa, Y; et al. Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats. ARCHIVES OF TOXICOLOGY 82:641-654(2008).
- Tatemichi, M; Iwasaki, M; et al. Association between polymorphisms in glutathione S-transferase Mu3 and IgG titer levels in serum against Helicobacter pylori. JOURNAL OF HUMAN GENETICS 54:557-563(2009).
