GSTM2
-
Official Full Name
glutathione S-transferase mu 2 (muscle) -
Overview
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. -
Synonyms
GSTM2;glutathione S-transferase mu 2 (muscle);glutathione S transferase M2 (muscle);glutathione S-transferase Mu 2;GST4;GST, muscle;GST class-mu 2;glutathione S-transferase 4;glutathione S-transferase M1;glutathione S-aryltransferase M2;glutathi
Recombinant Proteins
- Human
- Rhesus macaque
- Cynomolgus
- Chicken
- Mouse
- Rat
- Human
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- HEK293T
- E. coli
- His
- GST
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GSTM2 involved in several pathways and played different roles in them. We selected most pathways GSTM2 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of xenobiotics by cytochrome P | MGST3,EPHX1,MGST1,UGT2A1,GSTP1,GSTO1,UGT1A7C,GSTA,UGT1A3,GSTP2 |
| Chemical carcinogenesis | CYP2C50,GSTM5,UGT1A1,GSTM6,ADH2-1,UGT1A6B,EPHX1,CYP1B1,ALDH3B1,CYP2A13 |
| Glutathione metabolism | SRM,IDH2,SMS,GSTA5,GPX1,GPX4,GPX8,GPX7,GSTM1,GPX6 |
| Drug metabolism - cytochrome P | GSTT1,GSTA2,GSTT1B,GSTT2B,UGT2B7,GSTAL,GSTM4,GSTT2,GSTA4,UGT2A2 |
Protein Function
GSTM2 has several biochemical functions, for example, enzyme binding,glutathione binding,glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTM2 itself. We selected most functions GSTM2 had, and list some proteins which have the same functions with GSTM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | BCL11A,CRYBA2,UNC13A,ECE1,YARS2,SUPV3L1,NAMPT,PAFAH1B2,JUP,GAMT |
| glutathione transferase activity | EEF1E1,GSTP1,MGST1,GSTP2,GSTO1,GSTM3,GSTA5,GSTA2,GSTA4,GSTT1B |
| glutathione binding | GPX1,GSTM3,GSTM7,GSTP2,MGST1,PTGES,GSS,GSTM1,PTGESL,LANCL1 |
| enzyme binding | GSTM1,MST1R,RARA,PPP1R3D,EIF4E,HSPA2,PHKG2,SNRPD3,BACE1,HLCS |
| receptor binding | CD200,TIGIT,FASLG,PPP2R4,ABL1,CADM1A,ACOT8,PSPN,RASA1,TNFSF9 |
Interacting Protein
GSTM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTM2.
Resources
Related Services
Related Products
References
- Li, YJ; Yan, M; et al. Glutathione S-transferase Mu 2-transduced mesenchymal stem cells ameliorated anti-glomerular basement membrane antibody-induced glomerulonephritis by inhibiting oxidation and inflammation. STEM CELL RESEARCH & THERAPY 5:-(2014).
- Lim, J; Luderer, U; et al. Oxidative Damage Increases and Antioxidant Gene Expression Decreases with Aging in the Mouse Ovary. BIOLOGY OF REPRODUCTION 84:775-782(2011).
