GSTA5
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Official Full Name
glutathione S-transferase alpha 5 -
Overview
The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359). -
Synonyms
GSTA5;glutathione S-transferase alpha 5;glutathione S transferase A5;glutathione S-transferase A5;glutathione S transferase alpha 5;glutathione S transferase Yc 2;Glutathione S-transferase A5-5;GST A5 5;GST class-alpha member 5;GST Yc2;Gsta5 glutathione S transferase Yc2 subunit;GSTA5_HUMAN;glutathione transferase A5
Recombinant Proteins
- Rat
- Human
- Cynomolgus
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Gsta5-2014R | Recombinant Rat Gsta5 protein, His-tagged | E.coli | Rat | His | Met1~Ser221 |
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| GSTA5-4412H | Recombinant Human GSTA5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GSTA5-573C | Recombinant Cynomolgus GSTA5 Protein, His-tagged | Mammalian Cell | Cynomolgus | His |
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| GSTA5-849H | Recombinant Human GSTA5 | Mammalian Cell | Human | His |
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| GSTA5-5716HCL | Recombinant Human GSTA5 293 Cell Lysate | HEK293 | Human | Non |
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| GSTA5-3087H | Recombinant Human GSTA5 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| GSTA5-3087H-B | Recombinant Human GSTA5 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| GSTA5-319C | Recombinant Cynomolgus Monkey GSTA5 Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
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| GSTA5-319C-B | Recombinant Cynomolgus Monkey GSTA5 Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
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| GSTA5-3343HF | Recombinant Full Length Human GSTA5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 222 amino acids |
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Involved Pathway
GSTA5 involved in several pathways and played different roles in them. We selected most pathways GSTA5 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | ALDH3B2,GSTP2,CYP2E1,GSTA3,CYP2C19,AKR1C2,CYP2C39,SULT1A4,ALDH3B1,CCBL1 |
| Metabolism of xenobiotics by cytochrome P | AKR7A3,AKR7A5,DHDH,GSTP2,UGT1A6,ALDH3A1,GSTT2B,HSD11B1,UGT1AB,ALDH3B2 |
| Drug metabolism - cytochrome P | MAOA,UGT1A6A,MGST1.1,UGT1A1,UGT2B15,UGT1A2,UGT1A4,GSTT2B,GSTT1,AOX2P |
| Glutathione metabolism | ANPEP,GSTP1,GGT1A,GSTA2,RRM2,G6PD,GGT6,GPX4B,GGCTB,GGCT |
Protein Function
GSTA5 has several biochemical functions, for example, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTA5 itself. We selected most functions GSTA5 had, and list some proteins which have the same functions with GSTA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione transferase activity | GSTM7,EEF1E1,GSTT1B,GSTM1,MGST3,EEF1G,GSTA3,HPGDS,GDAP1,GSTA1 |
Interacting Protein
GSTA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTA5.
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References
- Miao, WM; Hu, LG; et al. Oltipraz is a bifunctional inducer activating both phase I and phase II drug-metabolizing enzymes via the xenobiotic responsive element. MOLECULAR PHARMACOLOGY 64:346-354(2003).
- Staffas, L; Ellis, EM; et al. Growth hormone- and testosterone-dependent regulation of glutathione transferase subunit A5 in rat liver. BIOCHEMICAL JOURNAL 332:763-768(1998).
