GRX1
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Official Full Name
glutaredoxin 1 -
Overview
GRX1 has a glutathione-disulfide oxidoreductase activity in the presence of nadph and glutathione reductase. reduces low molecular weight disulfides and proteins. Glutaredoxin is a glutathione (GSH)-dependent hydrogen donor for ribonucleotide reductase and also catalyzes glutathione-disulfide oxidoreduction reactions in the presence of NADPH and glutathione reductase. GRX1 is multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage. -
Synonyms
GRX;Glutaredoxin;Glutaredoxin 1;GLRX;GLRX1;GRX1;GRX-1;GLRX-1;MGC117407;TTase-1;Thioltransferase-1;Thioltransferase;OTTHUMP00000149979;glutaredoxin (thioltransferase);Glutathione-dependent oxidoreductase 1
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Involved Pathway
GRX1 involved in several pathways and played different roles in them. We selected most pathways GRX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GRX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
GRX1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by GRX1 itself. We selected most functions GRX1 had, and list some proteins which have the same functions with GRX1. You can find most of the proteins on our site.
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Interacting Protein
GRX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRX1.
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