GRSF1
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Official Full Name
G-rich RNA sequence binding factor 1 -
Overview
G-rich sequence factor 1 (GRSF-1) is a cytoplasmic protein that binds RNAs containing the G-rich element. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. GRSF-1 is up-regulated with prostate cancer progression and down regulated by the differentiating agents phenylacetate and phenylbutyrate. The function of GRSF-1 is uncharacterized, but potential roles include mRNA transport, stabilization, or translation. It might react with G-rich containing mRNA of Bcl2 and Bax indicating a regulation role of GRSF-1 in metastatic prostate cancer. -
Synonyms
GRSF1;G-rich RNA sequence binding factor 1;G-rich sequence factor 1;GRSF-1;FLJ13125
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| GRSF1-1982R | Recombinant Rhesus monkey GRSF1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| GRSF1-4430Z | Recombinant Zebrafish GRSF1 | Mammalian Cell | Zebrafish | His |
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| GRSF1-1803R | Recombinant Rhesus Macaque GRSF1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| GRSF1-1803R-B | Recombinant Rhesus Macaque GRSF1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| GRSF1-5384H | Recombinant Human GRSF1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GRSF1-5613HF | Recombinant Full Length Human GRSF1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 459 amino acids |
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Involved Pathway
GRSF1 involved in several pathways and played different roles in them. We selected most pathways GRSF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GRSF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
GRSF1 has several biochemical functions, for example, nucleic acid binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRSF1 itself. We selected most functions GRSF1 had, and list some proteins which have the same functions with GRSF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleic acid binding | EIF4A1B,POGZA,MARF1,KLF11B,RBMS3,U2AF2B,ZFP536,ZFP827,ZNF740B,RREB1 |
| nucleotide binding | UCK2A,RPS6KB1B,ABCD3B,MAT2AB,HUG,HNRNPA0B,HELZ,AKT2L,HNRNPF,EEF1A1L1 |
Interacting Protein
GRSF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRSF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRSF1.
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References
- Piekna-Przybylska, D; Sullivan, MA; et al. U3 Region in the HIV-1 Genome Adopts a G-Quadruplex Structure in Its RNA and DNA Sequence. BIOCHEMISTRY 53:2581-2593(2014).
- BIRNBAUM, MJ; WRIGHT, KL; et al. FUNCTIONAL-ROLE FOR SP1 IN THE TRANSCRIPTIONAL AMPLIFICATION OF A CELL-CYCLE-REGULATED HISTONE H4 GENE. BIOCHEMISTRY 34:7648-7658(1995).
