GRM6
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Official Full Name
glutamate receptor, metabotropic 6 -
Overview
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. -
Synonyms
GRM6;glutamate receptor, metabotropic 6;metabotropic glutamate receptor 6;GPRC1F;mGlu6;MGLUR6;CSNB1B;DKFZp686H1993
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRM6-679H | Recombinant Human GRM6 | Mammalian Cell | Human | His |
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| GRM6-3080H | Recombinant Human GRM6 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| GRM6-3080H-B | Recombinant Human GRM6 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| GRM6-5369H | Recombinant Human GRM6 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
GRM6 involved in several pathways and played different roles in them. We selected most pathways GRM6 participated on our site, such as Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipase D signaling pathway | AKT1,AGTR1A,GNA12,FYN,AGPAT4,GRM1,RRAS,AVPR1A,PDGFRA,PLD2 |
| Neuroactive ligand-receptor interaction | CNR1,TAAR64,TAAR12C,CHRNB2,TAAR14F,GABRQ,HTR1D,AVPR2,BDKRB1,LHB |
| Glutamatergic synapse | GNG4,GRIN2D,PLD1,GNAI1,GNG7,GRIK4,ITPR1,GNG8,SHANK1,PLA2G4F |
Protein Function
GRM6 has several biochemical functions, for example, G-protein coupled receptor activity,glutamate receptor activity,group III metabotropic glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM6 itself. We selected most functions GRM6 had, and list some proteins which have the same functions with GRM6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutamate receptor activity | GRM5,GRM2,GRIK5,GRM7,GRID2,GRM4,GRIK3,GRM1,GRIA1,GRM3 |
| G-protein coupled receptor activity | GPR115,OR4C13,RGRB,DRD2A,APLNRB,GPR35,OLFR473,OLFCD2,V2RH14,OPN1SW2 |
| protein homodimerization activity | CHMP1A,ZHX2,PAFAH1B1,PVRL1B,NR6A1A,MID1,SDCBP,PDK2,CEACAM5,SEPT12 |
| group III metabotropic glutamate receptor activity | GRM6B,GRM6A,GRM8,GRM7,GRM4 |
| protein binding | CELF1,PLK3,VDR,RGS1,FAM46D,FECH,GRIN1,ROPN1,GGT1,JUN |
Interacting Protein
GRM6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM6.
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