GRLF1
-
Official Full Name
glucocorticoid receptor DNA binding factor 1 -
Overview
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. -
Synonyms
p190A;AI841135;Arhgap35;mKIAA1722;p190RhoGAP;6430596G11Rik
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRLF1-2754H | Recombinant Human GRLF1 protein, His-tagged | E.coli | Human | His | 890-1080 aa |
Involved Pathway
GRLF1 involved in several pathways and played different roles in them. We selected most pathways GRLF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GRLF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
GRLF1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by GRLF1 itself. We selected most functions GRLF1 had, and list some proteins which have the same functions with GRLF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
GRLF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRLF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRLF1.
Resources
Related Services
Related Products
References
- Asai, A; Karnan, S; et al. High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas. GENE 558:220-226(2015).
- Cecchinato, A; Ribeca, C; et al. Candidate gene association analysis for milk yield, composition, urea nitrogen and somatic cell scores in Brown Swiss cows. ANIMAL 8:1062-1070(2014).
