GRK7
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Official Full Name
G protein-coupled receptor kinase 7 -
Overview
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. -
Synonyms
GRK7;G protein-coupled receptor kinase 7;GPRK7;g protein-coupled receptor kinase GRK7
Recombinant Proteins
- Human
- Sf9 Cells
- HEK293
- Insect Cells
- Wheat Germ
- In Vitro Cell Free System
- Sf21 Cells
- GST
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRK7-1021H | Recombinant Human G Protein-Coupled Receptor Kinase 7, GST-tagged | Sf9 Cells | Human | GST |
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| GRK7-753HCL | Recombinant Human GRK7 cell lysate | Human | Non |
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| GRK7-147H | Recombinant Human GRK7 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| GRK7-2357H | Recombinant Human GRK7 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| GRK7-5360H | Active Recombinant Human GRK7 Protein, GST-tagged | Insect Cells | Human | GST |
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| GRK7-5361H | Recombinant Human GRK7 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GRK7-5576HF | Recombinant Full Length Human GRK7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 553 amino acids |
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| GRK7-8988HF | Active Recombinant Full Length Human GRK7 Protein, GST-tagged | Sf21 Cells | Human | GST | Full L. 1-553 |
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Involved Pathway
GRK7 involved in several pathways and played different roles in them. We selected most pathways GRK7 participated on our site, such as Chemokine signaling pathway,Endocytosis,Inactivation, recovery and regulation of the phototransduction cascade, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inactivation, recovery and regulation of the phototransduction cascade | NMT2,RLN1,METAP1,CNGA1,NMT1B,SAGB,GNB5A,RGS9BP,NMT1,PPEF1 |
| Endocytosis | KIF5C,EPN2,NEDD4,SNF8,SNX12,KITA,CAV3,KIF5AA,ARFGEF2,ARF6A |
| Phototransduction | CALM1A,GNGT1,GC2,GNAT3,GUCA1A,RGS9B,GRK7A,GNAT2,RGS9,SAGA |
| The phototransduction cascade | RGS9BP,NMT1A,NMT1B,GUCA1E,SAGB,METAP2,METAP2B,METAP1,RLN1,METAP2A |
| Visual signal transduction: Cones | CNGA3,RDH12,ARR3,RLN1 |
| Chemokine signaling pathway | ADRBK2,GRK6,CCL3L3,IKBKG,AMCF-II,RAP1B,RLN1,GM13304,RAF1,CX3CR1 |
| Signal Transduction | RDH10,DCLRE1B,SKIB,OTULINB,PAG1,RGS9BP,EDN3,TULP3,RGS17,GRAP |
| Visual phototransduction | MYO7A,NMT1A,RLBP1,IRBP,APOM,STRA6,DHRS9,RLN1,BCO2L,APOA4B.1 |
Protein Function
GRK7 has several biochemical functions, for example, ATP binding,G-protein coupled receptor kinase activity,rhodopsin kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK7 itself. We selected most functions GRK7 had, and list some proteins which have the same functions with GRK7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PKN2,GC2,TAOK3,TARS,MYO10,PPP1CA,TTBK2,MYH7,DYRK2,MAP3K14 |
| rhodopsin kinase activity | RLN1,GRK4,GRK7A,GRK1B,GRK1,GRK1A,GRK7B |
| G-protein coupled receptor kinase activity | GRK1A,ADRBK2,GRK5,GRK1B,GRK7B,ADRBK1,RLN1,GRK1,GRK6,GRK7A |
Interacting Protein
GRK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK7.
HSP90AB1
GRK7 Related Signal Pathway
Resources
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References
- Hudson, NJ; Baker, ML; et al. Sensory Rewiring in an Echolocator: Genome-Wide Modification of Retinogenic and Auditory Genes in the Bat Myotis davidii. G3-GENES GENOMES GENETICS 4:1825-1835(2014).
- Tsutsui, K; Tachibanaki, S; et al. Different phosphorylation rates among vertebrate cone visual pigments with different spectral sensitivities. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 440:630-634(2013).
