GRHL1
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Official Full Name
grainyhead-like 1 (Drosophila) -
Overview
This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009] -
Synonyms
GRHL1;grainyhead-like 1 (Drosophila);MGR;NH32;LBP32;TFCP2L2;grainyhead-like protein 1 homolog;LBP protein 32;mammalian grainyhead;transcription factor LBP-32;transcription factor CP2-like 2
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRHL1-7253M | Recombinant Mouse GRHL1 Protein | Mammalian Cell | Mouse | His |
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| GRHL1-5751HCL | Recombinant Human GRHL1 293 Cell Lysate | HEK293 | Human | Non |
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| Grhl1-3304M | Recombinant Mouse Grhl1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| GRHL1-3920M | Recombinant Mouse GRHL1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GRHL1-3920M-B | Recombinant Mouse GRHL1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GRHL1-5325H | Recombinant Human GRHL1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GRHL1-5611HF | Recombinant Full Length Human GRHL1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 618 amino acids |
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Involved Pathway
GRHL1 involved in several pathways and played different roles in them. We selected most pathways GRHL1 participated on our site, such as Fatty acid, triacylglycerol, and ketone body metabolism,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of lipids and lipoproteins | ACER1,MTF1,ESRRA,GLTPA,AWAT2,MED25,ACAD11,CPTP,DECR1,CYP46A1 |
| PPARA activates gene expression | ANKRD1,MED10,GLIPR1,PLIN2,TIAM2,MED31,MED8,MED25,SREBF2,MED6 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED22,MED26,MED10,ANKRD1,PLIN2,MED9,MED16,MED20,MED25,MED31 |
| Metabolism | CYP2AD6,ADHFE1,CPNE3,CYP4F22,APOEA,FIG4,CYB5R3,LPA,OAZ2B,GLYAT |
| Fatty acid, triacylglycerol, and ketone body metabolism | ACOT7,ACOT8,CYP4A11,MTF1,CDK8,G0S2,MED19,MED23,MED26,PPARGC1B |
Protein Function
GRHL1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin DNA binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRHL1 itself. We selected most functions GRHL1 had, and list some proteins which have the same functions with GRHL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin DNA binding | HIST1H1E,XBP1,SRF,ACTN4,GRHL3,NEUROG3,FOXC2,PRDM14,SMAD3,ATOH1 |
| transcription regulatory region DNA binding | TFAP4,NKX2,H2AFY2,IKZF2,XRCC5,HIVEP3,THRA,SALL4,Ar,XBP1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | EN1,MYBL1,NR4A3,MIXL1,FOSL2,OTX1,NFE2L3,IFI16,MYOG,SOX1 |
| sequence-specific DNA binding | ISL2,CEBPG,ZBTB14,NR3C2,HOXC13A,NKX2.9,IKZF1,ZKSCAN14,HSFX1,NFE2L1B |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NFKB2,CEBPB,STAT3,HMGA2,YBX1,RUNX2,NCOA3,SMAD1,CEBPA,BSX |
Interacting Protein
GRHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRHL1.
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References
- Fabian, J; Lodrini, M; et al. GRHL1 Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3. CANCER RESEARCH 74:2604-2616(2014).
- Kohn, KW; Zeeberg, BM; et al. Gene Expression Correlations in Human Cancer Cell Lines Define Molecular Interaction Networks for Epithelial Phenotype. PLOS ONE 9:-(2014).
