GRB10
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Official Full Name
growth factor receptor-bound protein 10 -
Overview
Growth factor receptor-bound protein 10 and the insulin-like growth factor and the extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways in HEK 293T cells,In vivo. However, many aspects of the Grb10 adapter function remain unclear. Further research is still required to elucidate and validate the interactions and effects of GRB10 with various cellular targets. -
Synonyms
GRB10;growth factor receptor-bound protein 10;GRB10 adapter protein;GRB10 adaptor protein;maternally expressed gene 1;insulin receptor-binding protein Grb-IR;RSS;IRBP;MEG1;GRB-IR;Grb-10;KIAA0207
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
GRB10 involved in several pathways and played different roles in them. We selected most pathways GRB10 participated on our site, such as EGFR1 Signaling Pathway,IGF1 pathway,IRS activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin Signaling | CAP1,STXBP1A,ARHGAP33,MYO1C,STXBP4,GRB14,MAPK4,MAPK6,FLOT1,MAP3K10 |
| EGFR1 Signaling Pathway | KRT17,REPS1,PLSCR1,RALBP1,ZPR1,ERRFI1,RGS16,WNK1,PTK6,CEBPB |
| Insulin receptor signalling cascade | C7orf59,GRB10A,RRAGA,LAMTOR1,RRAGB |
| PDGFR-beta signaling pathway | SNX15,SLC9A3R1,DOK1,SLA |
| IGF1 pathway | GNB2L1 |
| Kit Receptor Signaling Pathway | GRAPA,PTPRUB,GRAP,DOK1B,SOCS4,GRB7,DOK1,PTPRU,STAP1,SPRED2B |
| Insulin Pathway | EXOC3,EXOC6,EXOC1,EXOC5,DOK1,GRB14 |
| IRS activation | GRB10A |
Protein Function
GRB10 has several biochemical functions, for example, SH3/SH2 adaptor activity,insulin receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB10 itself. We selected most functions GRB10 had, and list some proteins which have the same functions with GRB10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| insulin receptor binding | IRS1,PTPN11,INSL3,FRS2A,SNX1,FRS2B,DOK6,PIK3R1,SHC1,IGF1R |
| SH3/SH2 adaptor activity | HSH2D,SOCS2,LASP1,SKAP1,ARHGAP1,PTPN11,GRB14,SLA,SH3BGRL,CNTNAP1 |
| protein binding | SYCE3,NSMCE2,FXN,TRIM59,RNF20,ZBTB9,FSTL3,PYGM,PIP5K1B,EIF4A3 |
Interacting Protein
GRB10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB10 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB10.
EGFR;INSR;RCAN3;IGF1R;EPHB1;BAIAP2;ABI1;GRB2;ZDHHC17;NOA1
GRB10 Related Signal Pathway
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References
- Gorlova, O; Martin, JE; et al. Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy. PLOS GENETICS 7:-(2011).
- Higashi, S; Iseki, E; et al. GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation. JOURNAL OF NEUROCHEMISTRY 115:423-437(2010).
