GPX6
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Official Full Name
glutathione peroxidase 6 (olfactory) -
Overview
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Expression of this gene is restricted to embryos and adult olfactory epithelium. -
Synonyms
GPX6;glutathione peroxidase 6 (olfactory);glutathione peroxidase pseudogene 3 , GPXP3
Recombinant Proteins
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- His&T7
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Gpx6-1108M | Recombinant Mouse Gpx6 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Gln20~Gln221 |
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| Gpx6-1109R | Recombinant Rat Gpx6 protein, His & T7-tagged | E.coli | Rat | His&T7 | Gln20~Gln221 |
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| GPX6-2681R | Recombinant Rat GPX6 Protein | Mammalian Cell | Rat | His |
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| GPX6-7234M | Recombinant Mouse GPX6 Protein | Mammalian Cell | Mouse | His |
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| GPX6-2335R | Recombinant Rat GPX6 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GPX6-2335R-B | Recombinant Rat GPX6 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GPX6-3905M | Recombinant Mouse GPX6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GPX6-3905M-B | Recombinant Mouse GPX6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GPX6 involved in several pathways and played different roles in them. We selected most pathways GPX6 participated on our site, such as Glutathione metabolism,Arachidonic acid metabolism,Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | MGST3,GPX7,GGT5A,GSTA3,ANPEP,GSTP2,GPX4A,SRM,G6PDX,GPX1A |
| Arachidonic acid metabolism | AWAT1,MAPKAPK2B,CYP2U1,GGTLC1,ALOX5AP,CYP2N13,AKR1C6,PLA2G3,CYP2C37,CYP4F3 |
| Thyroid hormone synthesis | CREB5,ATP1B3,ITPR3,CREB3L2,ATP1B4,DUOXA2,FXYD2,HSPA5,GNAS,PRKCA |
Protein Function
GPX6 has several biochemical functions, for example, glutathione peroxidase activity,oxidoreductase activity,peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPX6 itself. We selected most functions GPX6 had, and list some proteins which have the same functions with GPX6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peroxidase activity | PXDN,PTGS2A,PRDX1,GPX1B,DUOX2,PTGS1,GPX4A,IPCEF1,MPX,GPX4B |
| glutathione peroxidase activity | MGST2,GSTK1,GPX3,LTC4S,GSTT1,GPX1,GPX4B,MGST1,GPX4A,GPX5 |
| oxidoreductase activity | CRYM,CYP3C1,CYP2K19,CYP1D1,CYP2D6,CYB561A3A,CYP2AA4,G6PDX,QDPRA,CYP2A12 |
Interacting Protein
GPX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPX6.
Resources
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References
- Leonard, B; Maes, M; et al. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 36:764-785(2012).
- Hashimoto, K; Ueda, S; et al. Neuroprotective effects of melatonin on the nigrostriatal dopamine system in the zitter rat. NEUROSCIENCE LETTERS 506:79-83(2012).
