GPS2
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Official Full Name
G protein pathway suppressor 2 -
Overview
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. -
Synonyms
GPS2;G protein pathway suppressor 2;GPS-2;AMF-1;MGC104294;MGC119287;MGC119288;MGC119289
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GPS2-11208Z | Recombinant Zebrafish GPS2 | Mammalian Cell | Zebrafish | His |
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| GPS2-306HCL | Recombinant Human GPS2 lysate | HEK293 | Human | Non |
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| GPS2-2243H | Recombinant Human GPS2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Gps2-3297M | Recombinant Mouse Gps2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| GPS2-5296H | Recombinant Human GPS2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GPS2-5560HF | Recombinant Full Length Human GPS2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 327 amino acids |
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| GPS2-6569H | Recombinant Human GPS2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
GPS2 involved in several pathways and played different roles in them. We selected most pathways GPS2 participated on our site, such as HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | WNT7B,HLA-DQB1,ATF4,HLA-F,RRAS2,POLB,SMAD4,CALR,ZFP36,CDC27 |
Protein Function
GPS2 has several biochemical functions, for example, GTPase inhibitor activity,protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPS2 itself. We selected most functions GPS2 had, and list some proteins which have the same functions with GPS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase inhibitor activity | CDC42SE1,UBE4A,TNK2,ARL2,IPO5,RTKN,GPS1,SLIT2,CPEB2,PDE6D |
| protein binding | PRKCI,ANXA5,EPHB6,RAD51C,MKKS,SEC24A,MAGEE1,TEX13A,DCDC2B,MYLK |
| transcription corepressor activity | ALX1,WWTR1,BRD7,SETD8,ZNF136,RUNX1T1,ZEB1,HDAC7A,HOXC6,ANKRD1 |
Interacting Protein
GPS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPS2.
E6;E6;ATF4;KRT31
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