GPR50

  • Official Full Name

    G protein-coupled receptor 50

  • Overview

    This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women.

  • Synonyms

    GPR50;G protein-coupled receptor 50;melatonin-related receptor;H9;Mel1c;G protein coupled receptor 50;GPR 50;MGC125342;MTNRL

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Sheep
  • Mus musculus
  • E.coli
  • Mammalian Cell
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • E.coli expression system
  • GST
  • His
  • Non
  • His&GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
GPR50-13478H Recombinant Human GPR50, GST-tagged E.coli Human GST C-term-323a.a.
GPR50-6913C Recombinant Chicken GPR50 Mammalian Cell Chicken His
GPR50-7191M Recombinant Mouse GPR50 Protein Mammalian Cell Mouse His
GPR50-746HCL Recombinant Human GPR50 cell lysate Human Non
GPR50-1144C Recombinant Chicken GPR50 Protein, His&GST-tagged E.coli Chicken His&GST Gly293-Leu346
GPR50-3881M Recombinant Mouse GPR50 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
GPR50-3881M-B Recombinant Mouse GPR50 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GPR50-5249H Recombinant Human GPR50 Protein Wheat Germ Human Non
GPR50-5250H Recombinant Human GPR50 Protein, GST-tagged Wheat Germ Human GST
GPR50-5595HF Recombinant Full Length Human GPR50 Protein In Vitro Cell Free System Human Full L. 572 amino acids
GPR50-5597HF Recombinant Full Length Human GPR50 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 617 amino acids
RFL23569OF Recombinant Full Length Sheep Melatonin-Related Receptor(Gpr50) Protein, His-Tagged E.coli expression system Sheep His Full L. Full Length (1-575)
RFL30550HF Recombinant Full Length Human Melatonin-Related Receptor(Gpr50) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-617)
RFL6637MF Recombinant Full Length Mouse Melatonin-Related Receptor(Gpr50) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-583)

    Involved Pathway

    GPR50 involved in several pathways and played different roles in them. We selected most pathways GPR50 participated on our site, such as GPCRs, Class A Rhodopsin-like,Neuroactive ligand-receptor interaction,Small Ligand GPCRs, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    GPCRs, Class A Rhodopsin-like AGTR2,GPR77,CCR3,OPN1SW,CCR9,GPR4,SSTR1,DRD3,CCR1,APLNR
    Neuroactive ligand-receptor interaction CHRM5A,PRSS2,HRH1,GALR2,MC1R,TSPO,GABRB2,PRLHR2B,GHSR,HTR2C

    Protein Function

    GPR50 has several biochemical functions, for example, G-protein coupled receptor activity,identical protein binding,melatonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR50 itself. We selected most functions GPR50 had, and list some proteins which have the same functions with GPR50. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor activity OLFR998,RXFP2B,GPR152,NPY8AR,OR2C1,OLFR507,GPR133,V2RX1,TACR1B,CD97
    melatonin receptor activity MTNR1BB,MTNR1AA,MTNR1BA,MTNR1A,MTNR1C,MTNR1B,MTNR1AL
    protein binding EHD1,MYLK2,CCBL1,RBM3,NLGN3,CALM2,NCLN,GJA1,BCL3,SEMA4D
    identical protein binding ADIPOQ,ASMT,REG3B,LCP1,SHARPIN,SMAD4,GOT1L1,SCAND1,RCAN1,RAF1

    Interacting Protein

    GPR50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR50 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR50.

    MT1A;ZNF572;MT2A;GNAI1

    Resources

    Research Area

    Nogo Proteins and Receptors

    References

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