GPR18
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Official Full Name
G protein-coupled receptor 18 -
Overview
N-arachidonyl glycine receptor also known as G-protein coupled receptor 18 (GPR18) is a protein that in humans is encoded by the GPR18 gene.Along with the other previously "orphan" receptors GPR55 and GPR119, GPR18 has been found to be a receptor for endogenous lipid neurotransmitters, several of which also bind to cannabinoid receptors. -
Synonyms
GPR18;G protein-coupled receptor 18;N-arachidonyl glycine receptor;NAGly receptor;G-protein coupled receptor 18
Recombinant Proteins
- Rat
- Cynomolgus
- Mouse
- Human
- Bovine
- Mus musculus
- Macaca fascicularis
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
GPR18 involved in several pathways and played different roles in them. We selected most pathways GPR18 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | ARHGEF9,GPR4,ADCYAP1,AGT,ADORA2A,NPSR1,PTH,S1PR3,NMBB,CCR1 |
| Signal Transduction | BCO2A,SOUL4,OXGR1A.3,MKS1,RAMP3,CNGA1,SST1.1,LGR5,RHOJ,PTPRK |
| G alpha (i) signalling events | RLN3A,HRH3,RGS7,CCR3,SST,NMU,RGS18,RGS12,S1PR1,PYYA |
| GPCR ligand binding | PROKR1A,SSTR1,ADORA2A,ADORA3,RAMP3,GPR37B,EDN3,NPFF,CRHR1,TAS2R3 |
| Signaling by GPCR | TAAR1,XK,GPR65,ARHGEF16,PENKB,DCLRE1B,SST1.1,GPRC6A,TRH,RGS11 |
| GPCRs, Other | CELSR2,ADORA3,VMN1R44,V1RA8,GPR183,S1PR1,EMR2,GPR84,VMN1R54,VMN1R47 |
| GPCRs, Class A Rhodopsin-like | NMUR1,FFAR3,GPR77,OPN1MW,GPR65,CCR3,GPR3,GPR4,CMKLR1,CNR1 |
| Class A/1 (Rhodopsin-like receptors) | LPAR5A,ADRA2B,SAA1,NPSR1,OPN1LW1,POMCB,OPN4.1,ADRB2,GPR132,CCL19A.2 |
Protein Function
GPR18 has several biochemical functions, for example, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR18 itself. We selected most functions GPR18 had, and list some proteins which have the same functions with GPR18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | TAAR10A,V2RH14,PTH1RB,HTR1AB,GPRC6A,OR10H1,NPFFR2.1,GPR146,OR51D1,RGR |
Interacting Protein
GPR18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR18 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR18.
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References
- Schoeder, CT; Rempel, V; et al. P2Y-like orphan receptors: new antagonist for GPR18 and GPR55. PURINERGIC SIGNALLING 10:785-785(2014).
- Qiu, W; Ciuclan, L; et al. Genetic deletion of GPR18 enhances immune responses to pathogenic and antigenic challenge. IMMUNOLOGY 143:180-180(2014).
