GPAM
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Official Full Name
glycerol-3-phosphate acyltransferase, mitochondrial -
Overview
This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathways first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. -
Synonyms
GPAM;glycerol-3-phosphate acyltransferase, mitochondrial;glycerol-3-phosphate acyltransferase 1, mitochondrial;glycerol 3 phosphate acyltransferase 1;mitochondrial;GPAT1;KIAA1560;MGC26846;GPAT-1;glycerol 3-phosphate acyltransferase, mitochondrial
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
GPAM involved in several pathways and played different roles in them. We selected most pathways GPAM participated on our site, such as Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid metabolism | DGKZ,GPD1A,PISD,DGKQ,ETNK2,AGPAT6,PLA2G10,PPAP2D,PPAP2CB,PLA2G4D |
| Metabolic pathways | ALDH4A1,POLA1,GMPPAB,B3GNT5B,ST6GALNAC1,PDHX,ALG12,PNAT10,MOGS,LDHBB |
| Glycerolipid metabolism | MOGAT2,ALDH3A2,DGKAA,ALDH9A1A.1,AKR1B10,DGKE,MOGAT3,ALDH7A1,Cel,AKR1A1A |
Protein Function
GPAM has several biochemical functions, for example, glycerol-3-phosphate O-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPAM itself. We selected most functions GPAM had, and list some proteins which have the same functions with GPAM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycerol-3-phosphate O-acyltransferase activity | AGPAT9,AGPAT6,AGPAT9L,GPAT2 |
Interacting Protein
GPAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPAM here. Most of them are supplied by our site. Hope this information will be useful for your research of GPAM.
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References
- Wang, S; Lee, DP; et al. Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2). ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 465:347-358(2007).
