GPAA1
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Official Full Name
glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) -
Overview
Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. -
Synonyms
GPAA1;glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast);anchor attachment protein 1 (Gaa1p, yeast) homolog , GPAA1P anchor attachment protein 1 homolog (yeast);glycosylphosphatidylinositol anchor attachment 1 protein;GAA1;GPI transamidase subunit;hGAA1;GPI anchor attachment protein 1;GAA1 protein homolog;GPAA 1;GPAA1P anchor attachment protein 1 homolog;glycophosphatidylinositol anchor attachment 1;anchor attachment protein 1 (Gaa1p, yeast) homolog
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
GPAA1 involved in several pathways and played different roles in them. We selected most pathways GPAA1 participated on our site, such as Glycosylphosphatidylinositol(GPI)-anchor biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GBE1,SAT1,ALDH18A1,ALDH9A1A.1,CMBL,DPM2,PNP6,DLDH,MIBP2,PRPS1 |
| Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | PIGN,PIGL,PIGF,PIGV,PIGQ,PIGYL,PIGO,PIGP,PIGW,PIGB |
Protein Function
GPAA1 has several biochemical functions, for example, contributes_to GPI anchor binding,contributes_to GPI-anchor transamidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPAA1 itself. We selected most functions GPAA1 had, and list some proteins which have the same functions with GPAA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tubulin binding | MTAP4,STMN2B,AGBL1,ATF5,EML1,TPR,CDK5RAP2,NCALD,STMN2,MTAP7D3 |
| contributes_to GPI anchor binding | PIGK |
| protein binding | TMEM93,ROBO1,GTF3C3,SOX9A,SEPT9,IL17RA,CYFIP2,ALS2CR11,CDC45,TFAP4 |
| contributes_to GPI-anchor transamidase activity | PIGS |
Interacting Protein
GPAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPAA1.
ALPP;EIF3E;PIN1;GRIK5;PRR13;Ptpn13;Rock1;PIGS
Resources
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References
- Sharma, DK; Hilley, JD; et al. Soluble GP18 restores glycosylphosphatidylinositol anchoring in a trypanosome cell-free system depleted of lumenal endoplasmic reticulum proteins. BIOCHEMICAL JOURNAL 351:717-722(2000).
