GP9
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Official Full Name
glycoprotein IX (platelet) -
Overview
This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. -
Synonyms
GPIX;CD42a;GP9 platelet glycoprotein IX;GP-IX;glycoprotein 9;OTTHUMP00000217111
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Mus musculus
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
- Fc
Background
What is GP9 Protein?
GP9 protein, or mucinous ovarian carcinoma (MOC), stands out as a rare subtype of epithelial ovarian cancer. MOC presents unique diagnostic and treatment challenges due to its distinct biological behavior and relatively better prognosis when diagnosed early. It is often confused with metastatic mucinous adenocarcinomas, making differentiation crucial. Characteristically, MOC is more common in younger women and is usually detected at an early stage, leading to higher survival rates. However, once it advances, the prognosis worsens markedly, partly because standard chemotherapy tends to be less effective against it. Notably, MOC often exhibits specific genetic mutations, such as alterations in the KRAS gene. Ongoing research efforts are focused on understanding these molecular characteristics to develop more effective targeted therapies. Understanding the importance of accurate diagnosis and management strategies is critical in improving outcomes for patients with MOC.What is the Function of GP9 Protein?
So, GP9 protein, also known as glycoprotein IX platelet, is like a little helper in our body. It's part of a bigger team called the GPIb-IX-V complex. GP9 teams up with this other protein, glycoprotein Ib, and they cling to the sides of our blood vessels. That's a vital part of making a blood clot. If something goes awry with the GP9 gene, it can mess things up and lead to this thing called Bernard-Soulier syndrome. People with that have these huge platelets and can struggle with bleeding. So, GP9 is like a tiny superhero working behind the scenes to keep us healthy and make sure our blood clots when we need it to. It's a pretty important job, and GP9 does it really well!GP9 Related Signaling Pathway
GP9, or glycoprotein IX platelet, is a key player in the GPIb-IX-V complex, which acts like a superhero team in our body. Their main gig is to jump into action and help our blood clot when we get injured, kinda like the first responders at the scene of an accident. GP9 teams up with glycoprotein Ib and sticks to the walls of our blood vessels to kickstart the clotting process. It's part of a signaling pathway that sends out the SOS to get our body to respond quickly. If GP9's not doing its job right, due to a glitch in its gene, it can lead to issues like excessive bleeding, as seen in Bernard-Soulier syndrome. So, GP9 and its crew are the behind-the-scenes heroes making sure our blood clots when we need it, keeping us healthy and safe.GP9 Related Diseases
GP9 protein is like a tiny helper in our body. It helps our blood clot when we get hurt. But if GP9 isn't working right, it can cause a condition called Bernard-Soulier syndrome. People with this have big platelets and might bleed more easily. It's like the helper isn't doing its job, so doctors step in to help fix things.Bioapplications of GP9
GP9, known as glycoprotein IX platelet, is vital for blood clotting as part of the GPIb-IX-V complex. It's crucial for platelets to stick together and form clots. When GP9 doesn't work properly, it can lead to conditions like Bernard-Soulier syndrome, where patients have enlarged platelets and a higher risk of bleeding. In the lab, GP9 is a key focus for researchers studying how blood clots form and how to treat related disorders. It helps in testing new drugs that aim to improve blood clotting, making it a significant asset in medical research and development.Quality Guarantee
High Purity
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Fig1. SDS-PAGE (GP9-5133H) -
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Fig2. SDS-PAGE (GP9-823H)
Involved Pathway
GP9 involved in several pathways and played different roles in them. We selected most pathways GP9 participated on our site, such as ECM-receptor interaction,Platelet activation,Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with GP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ECM-receptor interaction | COL4A1,TNW,LAMA2,COL2A1A,SV2B,COL4A6,COL1A1B,LAMB3,ITGA10,LAMA4 |
| Platelet activation | PTGIR,ARHGEF1,MAPK12,PRKACA,PRKACG,PIK3R3,GUCY1B3,FGA,ACTB,MAPK11 |
| Hematopoietic cell lineage | Fcer2a,IL1R1,IL5,CD1A,CD8A,THPO,CD9,GP5,CSF1,IL7 |
Protein Function
GP9 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GP9 itself. We selected most functions GP9 had, and list some proteins which have the same functions with GP9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | STAT5A,HGD,MBD3,CTNNAL1,TTC25,PSIP1,GDAP2,SCNM1,COMMD10,C7orf42 |
Interacting Protein
GP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of GP9.
SPRY2;GP1BA;HOXA1;GP5;APPBP2;CRK;Hoxa1;GP1BB
Resources
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References
- Bragadottir, G; Birgisdottir, ER; et al. Clinical phenotype in heterozygote and biallelic Bernard-Soulier syndrome-A case control study. AMERICAN JOURNAL OF HEMATOLOGY 90:149-155(2015).
- Hassapis, KA; Stylianou, DC; et al. Architectural Insight into Inovirus-Associated Vectors (IAVs) and Development of IAV-Based Vaccines Inducing Humoral and Cellular Responses: Implications in HIV-1 Vaccines. VIRUSES-BASEL 6:5047-5076(2014).
