GLRA3
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Official Full Name
glycine receptor, alpha 3 -
Overview
The GLRA3 gene encodes the alpha-3 subunit of the neuronal glycine receptor, a ligand-gated chloride channel composed;of ligand-binding alpha and structural beta polypeptides (Kingsmore et al., 1994 (PubMed 7894176)). -
Synonyms
GLRA3;glycine receptor, alpha 3;glycine receptor subunit alpha-3;GLRA 3;GLRA3_HUMAN;Glycine receptor alpha 3 polypeptide;Glycine receptor alpha 3 subunit;Glycine receptor subunit alpha 3;Ligand gated ion channel;OTTHUMP00000194692;OTTHUMP00000194693;glycine receptor, alpha-3 polypeptide
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GLRA3-13309H | Recombinant Human GLRA3, GST-tagged | E.coli | Human | GST | 28-254a.a. | |
| GLRA3-3003H | Recombinant Human GLRA3 protein, His-tagged | E.coli | Human | His | 29-255 aa | |
| GLRA3-9431Z | Recombinant Zebrafish GLRA3 | Mammalian Cell | Zebrafish | His |
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| GLRA3-4974H | Recombinant Human GLRA3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GLRA3-5345HF | Recombinant Full Length Human GLRA3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 34-464 amino acids |
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Involved Pathway
GLRA3 involved in several pathways and played different roles in them. We selected most pathways GLRA3 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLRA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | CHRNA1,NPY8BR,MC5RA,GH1,SSTR4,RXFP1,PTGER3,AVPR1B,APLNRB,MC3R |
Protein Function
GLRA3 has several biochemical functions, for example, contributes_to extracellular-glycine-gated chloride channel activity,contributes_to glycine binding,transmitter-gated ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GLRA3 itself. We selected most functions GLRA3 had, and list some proteins which have the same functions with GLRA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to extracellular-glycine-gated chloride channel activity | GLRBA,GLRA1,GLRB,GLRA4B |
| transmitter-gated ion channel activity | GLRA1,GLRA2,GLRA4B,SIX2A,GLRA4A |
| contributes_to glycine binding | GLRBA,GLRA4B,GLRA4A,GLRB,GLRBB,SIX2A |
Interacting Protein
GLRA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLRA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLRA3.
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References
- Eichler, SA; Forstera, B; et al. Splice-specific roles of glycine receptor alpha 3 in the hippocampus. EUROPEAN JOURNAL OF NEUROSCIENCE 30:1077-1091(2009).
- Majumdar, S; Weiss, J; et al. Glycinergic input of widefield, displaced amacrine cells of the mouse retina. JOURNAL OF PHYSIOLOGY-LONDON 587:3831-3849(2009).
