GLIS2
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Official Full Name
GLIS family zinc finger 2 -
Overview
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this proteins C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys. -
Synonyms
GLIS2;GLIS family zinc finger 2;zinc finger protein GLIS2;nephrocystin 7;NPHP7;FLJ38247;GLI similar 2;GLIS 2;Kruppel like zinc finger protein GLIS2;GLI-similar 2;nephrocystin-7;GLI-similar protein 2;neuronal Krueppel-like protein;Kruppel-like zinc finger protein GLIS2;NKL
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GLIS2-295H | Recombinant Human GLIS2 Protein, His-tagged | E.coli | Human | His |
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| GLIS2-6409M | Recombinant Mouse GLIS2 Protein | Mammalian Cell | Mouse | His |
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| GLIS2-3597M | Recombinant Mouse GLIS2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GLIS2-3597M-B | Recombinant Mouse GLIS2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GLIS2-4963H | Recombinant Human GLIS2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GLIS2-5333HF | Recombinant Full Length Human GLIS2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 524 amino acids |
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Involved Pathway
GLIS2 involved in several pathways and played different roles in them. We selected most pathways GLIS2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GLIS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
GLIS2 has several biochemical functions, for example, DNA binding,metal ion binding,nucleic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLIS2 itself. We selected most functions GLIS2 had, and list some proteins which have the same functions with GLIS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | FOXA1,SALL4,REST,SMARCA2,ARID5B,SMAD3,OVOL2,TFAP2A,TCF7,NR5A2 |
| DNA binding | ZBTB6,PHC3,CDX1A,ZNF234,ZC3H3,ZFP36L1,HOXC11A,RTEL1,SUPT3H,SLC2A4RG |
| nucleic acid binding | RNASE4,HDLBPA,SRSF6B,ZNF728,ZFP740,ZFP775,ZFPM1,BRD9,TDRKH,EGR2A |
| metal ion binding | CYP2K6,ADNP2,FIZ1,ZFP27,ISL2A,NUDT10,FAHD1,CRYAA,VEZF1,PPP4C |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | GRHL1,RFX4,NFKB2,ONECUT3,SMAD4,MYC,FOXC2,HOXA7,SOX1,TP53 |
| transcription factor activity, sequence-specific DNA binding | ETS1,FOXL2,ZFP28,HOXB7A,MESPBA,STAT5A,TAF4B,ZNF436,FOXG1A,MYCB |
| protein binding | PLP2,IPO7,TMEM11,SPPL3,MRPL4,DCTN3,ZWILCH,GPSM3,KRT38,SULT4A1 |
Interacting Protein
GLIS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLIS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLIS2.
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References
- Schuback, HL; Alonzo, TA; et al. CBFA2T3-GLIS2 Fusion Is Prevalent in Younger Patients with Acute Myeloid Leukemia and Associated with High-Risk of Relapse and Poor Outcome: A Children's Oncology Group Report. BLOOD 124:-(2014).
- Togni, M; Masetti, R; et al. DHH-RHEBL1 Fusion Transcript: A Novel Recurrent Feature in the New Landscape of Pediatric CBFA2T3-GLIS2-Positive Acute Myeloid Leukemia. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 36:E257-E257(2014).
