GLCE
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Official Full Name
glucuronic acid epimerase -
Overview
Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of;circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic;acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines;(Ghiselli and Agrawal, 2005 (PubMed 15853773)). -
Synonyms
GLCE;glucuronic acid epimerase;D glucuronyl C5 epimerase , UDP glucuronic acid epimerase;D-glucuronyl C5-epimerase;heparan sulfate epimerase;HSEPI;KIAA0836;D glucuronyl C5 epimerase;Heparin/heparan sulfate:glucuronic acid C5 epimerase;glucuronyl C5-epimerase;UDP-glucuronic acid epimerase;heparin/heparan sulfate-glucuronic acid C5-epimerase;heparin/heparan sulfate:glucuronic acid C5-epimerase
Recombinant Proteins
- Rhesus macaque
- Mouse
- Human
- Bovine
- Mammalian Cell
- HEK293
- Wheat Germ
- E.coli
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
GLCE involved in several pathways and played different roles in them. We selected most pathways GLCE participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLCE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | NDST3,EXTL1,EXT1C,MAPK1IP1L,HS6ST1A,NDST2,HS6ST1,HS6ST3,EXT2,HS6ST1B |
| Metabolic pathways | B4GALT4,UGT1A4,PGS1,ADK,POLR3C,SYNJ2,ALOX15,PNPLA2,SLC33A1,LSS |
Protein Function
GLCE has several biochemical functions, for example, UDP-glucuronate 5-epimerase activity,heparosan-N-sulfate-glucuronate 5-epimerase activity,racemase and epimerase activity, acting on carbohydrates and derivatives. Some of the functions are cooperated with other proteins, some of the functions could acted by GLCE itself. We selected most functions GLCE had, and list some proteins which have the same functions with GLCE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| racemase and epimerase activity, acting on carbohydrates and derivatives | FUOM,GLCEA,GLCEB |
| heparosan-N-sulfate-glucuronate 5-epimerase activity | GLCEA |
Interacting Protein
GLCE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLCE here. Most of them are supplied by our site. Hope this information will be useful for your research of GLCE.
PPM1D;BCAR3;BAG4;ESR1;ERBB2;FGFR2;FGFR4;PAX2;CASP8;RB1CC1
Resources
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References
- Qin, Y; Ke, JY; et al. Structural and Functional Study of D-Glucuronyl C5-epimerase. JOURNAL OF BIOLOGICAL CHEMISTRY 290:4620-4630(2015).
- Li, J; Fang, JP; et al. GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling. BIOCHEMICAL JOURNAL 459:405-415(2014).
