GIPC1
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Official Full Name
GIPC PDZ domain containing family, member 1 -
Overview
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008;(PubMed 18775991)). -
Synonyms
GIPC1;GIPC PDZ domain containing family, member 1;C19orf3, chromosome 19 open reading frame 3 , regulator of G protein signalling 19 interacting protein 1 , RGS19IP1;PDZ domain-containing protein GIPC1;GIPC;GLUT1CBP;Hs.6454;NIP;SEMCAP;SYNECTIN;TIP 2;C19ORF3;Chromosome 19 open reading frame 3;GLUT1 C terminal binding protein;IGF 1 receptor interacting protein 1;IIP 1;IIP1;Regulator of G protein signalling 19 interacting protein 1;RGS19 interacting protein 1;RGS19IP1;SYNECTIIN;Tax interaction protein 2;RGS19-interacting protein 1;RGS-GAIP-interacting protein;GLUT1 C-terminal binding protein;GAIP C-terminus-interacting protein;IGF-1 receptor interacting protein 1;regulator of G-protein signalling 19 interacting protein 1;IIP-1;TIP-2
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- T7
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
GIPC1 involved in several pathways and played different roles in them. We selected most pathways GIPC1 participated on our site, such as Neurotrophic factor-mediated Trk receptor signaling,Syndecan-4-mediated signaling events,TGF-beta Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GIPC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neurotrophic factor-mediated Trk receptor signaling | RIT1,DYNLT1,RGS19,FAIM,MCF2L,RIT2 |
| TGF-beta Receptor Signaling Pathway | STRAP,JUNBA,ENG,NFYBB,ZEB2A,SNIP1,SKIA,VDRB,TGFBR3,EID2 |
| Syndecan-4-mediated signaling events | ADAM12,MDK |
Protein Function
GIPC1 has several biochemical functions, for example, PDZ domain binding,actin binding,myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GIPC1 itself. We selected most functions GIPC1 had, and list some proteins which have the same functions with GIPC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | ACVR2A,GRIK5,SDC2,PLEKHA1,GRIK2,SLC9A3R1,MAP2K2,GRIA1,FZD3,SNTB1 |
| actin binding | EPS8L2,LMOD2,ALDOA,PARVA,MYH6,MYRIP,MYH1E,PARVAA,NF2,PLEC |
| protein binding | ZNF410,HIST1H4J,NCKIPSD,SDCBP2,NOS3,CDC5L,ATP2B4,TLE2,RYBP,TXNRD2 |
| myosin binding | CALM,CALD1,SLC6A4,ACTA1,VAMP2,CALD1B,FXYD1,RHOA,DMD,USH2A |
| protein homodimerization activity | TENM1,HAND1,PDK2,GNB2L1,SPPL2B,FZD9,FGFR1OP2,TP53I3,NR2F2,ERBB4 |
| receptor binding | MLN,IFNL3,ANGPTL1,NRG2,PPY,ANGPTL2,LRRC4B,FGG,Fgf15,RSPO3 |
Interacting Protein
GIPC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GIPC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GIPC1.
E6;TYRP1;TGFBR3;TPBG;42734339;MYO1C;BCR;PRKCA;SDC4;MCM7;COPB2;SSR4
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References
- Sensoy, O; Weinstein, H; et al. A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1848:976-983(2015).
- Solomon, O; Bazak, L; et al. Characterizing of functional human coding RNA editing from evolutionary, structural, and dynamic perspectives. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 82:3117-3131(2014).
