GINS4
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Official Full Name
GINS complex subunit 4 -
Overview
SLD5 or GINS4 is a member of the GINS complex which is involved in initiation of replication and unwinding of DNA. It is highly conserved amongst eukaryotes. The GINS complex in yeast associates with DNA polymerase epsilon and stimulates its catalytic activity. It also interacts with Cdc45 and the MCM2-7 complex to activate the eukaryotic minichromosome maintenance helicase. -
Synonyms
GINS complex subunit 4;GINS4;SLD5 homolog;SLD5;MGC14799;GINS complex subunit 4 (Sld5 homolog);2810037C03Rik;4933405K01Rik;DNA replication complex GINS protein SLD5
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Zebrafish
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
GINS4 involved in several pathways and played different roles in them. We selected most pathways GINS4 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,DNA Replication, which may be useful for your reference. Also, other proteins which involved in the same pathway with GINS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Replication | RNASEH2B,MCM7,PRIM1,MCM2,LIG1,POLE2,POLD4,PCNA,MCM3L,rnhA |
| S Phase | GINS1,MYCA,GINS2,ESCO1,ESCO2,GINS3 |
| DNA strand elongation | GINS1,GINS2,GINS3,DNA2 |
| Synthesis of DNA | GINS2,GINS3,GINS1 |
| Cell cycle | MCM10,KIF20A,TEX15,MAPRE1A,AKAP9,ANAPC11,GINS1,CDK11A,KIF18A,ANAPC7 |
| Cell Cycle, Mitotic | TCTN2,SGOL2,PDS5B,NCAPH2,LEMD3,OFD1,DYNC1H1,PLK4,E2F4,CLASP1A |
| Unwinding of DNA | GINS2,GINS3,GINS1 |
Protein Function
GINS4 has several biochemical functions, for example, contributes_to 3-5 DNA helicase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GINS4 itself. We selected most functions GINS4 had, and list some proteins which have the same functions with GINS4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to 3-5 DNA helicase activity | GINS2 |
| protein binding | TSG101,LDHA,CEACAM1,ZMYND11,APOA4,SFN,CST3,ITPR1,PAFAH1B1,LRRC3 |
Interacting Protein
GINS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GINS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GINS4.
GINS2;MCMBP;RPA2;RPA1;RPA3;Clspn;Tipin;Timeless
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