GH2
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Official Full Name
growth hormone 2 -
Overview
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. -
Synonyms
GH2;growth hormone 2;growth hormone variant;GH V;GHL;GHV;hGH V;placenta specific growth hormone;placental specific growth hormone;GH 2;hGHV;placenta-specific growth hormone;placental-specific growth hormone;GH-V;hGH-V
Recombinant Proteins
- Zebrafish
- Human
- Zebrafish
- E.coli
- Human
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- Non
- His
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| gh1-645Z | Recombinant Zebrafish Growth Hormone 1 Mutant | Zebrafish | Zebrafish | Non |
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| GH2-29022TH | Recombinant Human GH2 | E.coli | Human | Non | Full L. |
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| GH2-348H | Recombinant Human Growth Hormone 2 | Human | Human | Non |
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| GH2-67H | Recombinant Human Growth Hormone 2 | E.coli | Human | Non |
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| GH2-941H | Recombinant Human GH2 Protein, His-tagged | E.coli | Human | His |
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| GH2-292HCL | Recombinant Human GH2 lysate | HEK293 | Human | Non |
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| GH2-3047H | Recombinant Human GH2 Protein (Phe27-Phe217), N-His tagged | E.coli | Human | His | Phe27-Phe217 |
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| GH2-4884H | Recombinant Human GH2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GH2-5249HF | Recombinant Full Length Human GH2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 27-217 amino acids |
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Involved Pathway
GH2 involved in several pathways and played different roles in them. We selected most pathways GH2 participated on our site, such as Cytokine-cytokine receptor interaction,Neuroactive ligand-receptor interaction,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | SOCS9,JAK2B,FHL1B,GRB2A,GHR,IL23R,IFNA10,IL3,Ifna11,PTPN11B |
| PIK-Akt signaling pathway | MAP2K1,ATF4,CREB3L2,LPAR3,COL24A1,COL27A1,Itga10&Itgb1,CREB3L3,LAMB2,BRCA1 |
| Cytokine-cytokine receptor interaction | IL1R1,KITLGB,IL18,CNTF,RELT,TNFRSF10C,CCL22,TNFSF11,PRL,CCL28 |
| Neuroactive ligand-receptor interaction | HTR2CL1,TAAR13B,GABRA5,TAAR12H,TRHRB,LHB,TAAR12F,HRH2,SCTR,P2RX4 |
Protein Function
GH2 has several biochemical functions, for example, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GH2 itself. We selected most functions GH2 had, and list some proteins which have the same functions with GH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hormone activity | SST,INSL5,ADM,PRL8A9,GUCA2A,INSL4,PRL2C3,INHBA,STC2,GNRH3 |
Interacting Protein
GH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GH2.
Resources
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References
- Cairns, TM; Friedman, LS; et al. N-terminal mutants of herpes simplex virus type 2 gH are transported without gL but require gL for function. JOURNAL OF VIROLOGY 81:5102-5111(2007).
- Blouzard, JC; Bourgeois, C; et al. Enzyme diversity of the cellulolytic system produced by Clostridium cellulolyticum explored by two-dimensional analysis: Identification of seven genes encoding new dockerin-containing proteins. JOURNAL OF BACTERIOLOGY 189:2300-2309(2007).
