GFRA4
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Official Full Name
GDNF family receptor alpha 4 -
Overview
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
GFRA4;GDNF family receptor alpha 4;GDNF family receptor alpha-4;persephin receptor;GDNF receptor alpha-4;GDNFR-alpha-4;GFR alpha 4;GFR receptor alpha 4;GFR-alpha-4;GFRA4_HUMAN;Glial cell line derived neurotrophic factor family receptor alpha 4;Neurotrophic factor receptor splice variant A (Gfra4 gene);OTTHUMP00000030106;OTTHUMP00000030107
Recombinant Proteins
- Rat
- Chicken
- Human
- Mammalian Cell
- CHO
- HEK293
- His
- Flag
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GFRA4-2515R | Recombinant Rat GFRA4 Protein | Mammalian Cell | Rat | His |
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| GFRA4-6549C | Recombinant Chicken GFRA4 | Mammalian Cell | Chicken | His |
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| GFRA4-715H | Recombinant Human GFRA4 Protein, His-tagged | CHO | Human | His |
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| GFRA4-5951HCL | Recombinant Human GFRA4 Cell Lysate, transcript variant 1 | HEK293 | Human | Flag |
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| GFRA4-5952HCL | Recombinant Human GFRA4 Cell Lysate, transcript variant 2 | HEK293 | Human | Flag |
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| GFRA4-2171R | Recombinant Rat GFRA4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GFRA4-2171R-B | Recombinant Rat GFRA4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
GFRA4 involved in several pathways and played different roles in them. We selected most pathways GFRA4 participated on our site, such as Axon guidance,Developmental Biology,NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFRA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | SEMA6A,SEMA4B,DUSP5,EPHA2A,AP2B1,EPHB4A,SEMA5B,SLIT3,CREB1B,DAB2IPB |
| NCAM1 interactions | COL9A1A,GDNF,PSPN,GFRA1,NRTN,GFRA2,COL9A1B |
| Developmental Biology | GFRA1,EFNA1B,TRPC4,DRAP1,CACNG2B,NRTN,AP2A2,RGMB,ARPC3,CHL1 |
| NCAM signaling for neurite out-growth | COL9A1B,GFRA2,PSPN,NRTN,COL9A1A,ST8SIA2,GDNF,GFRA1 |
Protein Function
GFRA4 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GFRA4 itself. We selected most functions GFRA4 had, and list some proteins which have the same functions with GFRA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glial cell-derived neurotrophic factor receptor activity | GFRA2,GFRA1 |
Interacting Protein
GFRA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFRA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFRA4.
Resources
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References
- Liu, W; Rask-Andersen, H; et al. Immunohistological analysis of neurturin and its receptors in human cochlea. AURIS NASUS LARYNX 41:172-178(2014).
- Gassei, K; Ehmcke, J; et al. Magnetic activated cell sorting allows isolation of spermatogonia from adult primate testes and reveals distinct GFRa1-positive subpopulations in men. JOURNAL OF MEDICAL PRIMATOLOGY 39:83-91(2010).
