GFI1
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Official Full Name
growth factor independent 1 transcription repressor -
Overview
This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
GFI1;growth factor independent 1 transcription repressor;SCN2;GFI-1;GFI1A;ZNF163;zinc finger protein Gfi-1;zinc finger protein 163;growth factor independence-1;growth factor independent protein 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
GFI1 involved in several pathways and played different roles in them. We selected most pathways GFI1 participated on our site, such as Validated targets of C-MYC transcriptional repression, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Validated targets of C-MYC transcriptional repression | ZFP36L1,TMEM126A,S100A7,MXD4,LGALS1,CSDE1,CLU,SFXN3,DNTT,NDRG1 |
Protein Function
GFI1 has several biochemical functions, for example, protein binding,transcription regulatory region DNA binding,transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GFI1 itself. We selected most functions GFI1 had, and list some proteins which have the same functions with GFI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TRIM35-22,PTPN1,MMP8,RNF125,WBP4,PHC2B,ADH8B,TAB2,FHL3,NR2F1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | SREBF2,CC2D1A,ZFPM2A,HMGA2,ZFP746,PITX2,MYPOP,NFATC4,TFAP2A,ZNF148 |
| transcription regulatory region DNA binding | SOX5,REST,NKX3,GRHL1,SP1,CDK9,ZFP746,MESP1,PROX1,TFAP2A |
| protein binding | VCPKMT,C16orf59,EIF2B4,OTOF,SPTA1,RXFP4,YWHAQ,RPS19BP1,BIN2,YEATS4 |
Interacting Protein
GFI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFI1.
Ajuba;PRDM5;HDAC1;CHAF1A;TP53;Spi1;SPI1;RELA
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References
- Munnamalai, V; Hayashi, T; et al. Notch Prosensory Effects in the Mammalian Cochlea Are Partially Mediated by Fgf20. JOURNAL OF NEUROSCIENCE 32:12876-12884(2012).
- Li, L; Nishio, J; et al. Differential Response of Regulatory and Conventional CD4(+) Lymphocytes to CD3 Engagement: Clues to a Possible Mechanism of Anti-CD3 Action?. JOURNAL OF IMMUNOLOGY 191:3694-3704(2013).
