GEN1
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Official Full Name
Gen homolog 1, endonuclease (Drosophila) -
Synonyms
GEN1;Gen homolog 1, endonuclease (Drosophila);flap endonuclease GEN homolog 1;FLJ40869;Gen;DKFZp781F0986;GEN 1;Gen homolog 1 endonuclease (Drosophila);Gen homolog 1 endonuclease;GEN_HUMAN;OTTHUMP00000149987
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GEN1-6305M | Recombinant Mouse GEN1 Protein | Mammalian Cell | Mouse | His |
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| GEN1-5957HCL | Recombinant Human GEN1 293 Cell Lysate | HEK293 | Human | Non |
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| GEN1-3533M | Recombinant Mouse GEN1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GEN1-3533M-B | Recombinant Mouse GEN1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GEN1 involved in several pathways and played different roles in them. We selected most pathways GEN1 participated on our site, such as DNA Double-Strand Break Repair,DNA Repair,HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), which may be useful for your reference. Also, other proteins which involved in the same pathway with GEN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Repair | EME2,RAD9,PARP2,YY1A,MGMT,ERCC8,CLSPN,APITD1,PPIE,DNA2 |
| DNA Double-Strand Break Repair | KDM4A,CHEK1,TDP2,BABAM1,THRSP,EME2,KDM4B,KIAA0146,RAD9A,RNF4 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | KIAA0146,RAD51AP1 |
| HDR through Homologous Recombination (HRR) | HUS1,RBBP8,FUZ,EME1,RAD9,KIAA0146,EME2,RTEL1,RAD51AP1,TOPBP1 |
| Resolution of D-Loop Structures | RTEL1,RAD51AP1,KIAA0146,EME2 |
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | HUS1,PPP4CA,PPP4CB,RAD51AP1,FAM175A,PPP4R2B,BRE,PPP4R2,RAD1,RNF4 |
| Homology Directed Repair | TOPBP1,RAD51AP1,EME2,PPP4R2B,WRN,FUZ,PPP4R2A,RNF4,RTEL1,TIMELESS |
Protein Function
GEN1 has several biochemical functions, for example, DNA binding,crossover junction endodeoxyribonuclease activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GEN1 itself. We selected most functions GEN1 had, and list some proteins which have the same functions with GEN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | POU3F2A,ZBTB6,ZSCAN18,RBPJ,TSN,HOXC12,SP1,RC3H2,HISTH1L,NFATC2 |
| crossover junction endodeoxyribonuclease activity | SLX1B |
| metal ion binding | DGKE,CAR7,MMP14A,NR6A1B,GALNT9,RNF148,PDZRN3B,OVOL1,ZFP639,THAP6 |
Interacting Protein
GEN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GEN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GEN1.
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References
- Klein, JE; Estochen, EG; et al. THERMAL ENHANCEMENT CARTRIDGE HEATER MODIFIED (TECH MOD) TRITIUM HYDRIDE BED DEVELOPMENT PART I - DESIGN AND FABRICATION. FUSION SCIENCE AND TECHNOLOGY 67:371-374(2015).
- Freeman, ADJ; Liu, Y; et al. GEN1 from a Thermophilic Fungus Is Functionally Closely Similar to Non-Eukaryotic Junction-Resolving Enzymes. JOURNAL OF MOLECULAR BIOLOGY 426:3946-3959(2014).
